CELL-MEDIATED-IMMUNITY TO ACETALDEHYDE IN ALCOHOLIC LIVER-DISEASE DEMONSTRATED BY LEUKOCYTE MIGRATION TEST

被引：22

作者：

ACTIS, GC ^{[1
]}

PONZETTO, A ^{[1
]}

RIZZETTO, M ^{[1
]}

VERME, G ^{[1
]}

机构：

[1] OSPED MAURIZIANO, DEPT GASTROENTEROL, I-10128 TURIN, ITALY

来源：

AMERICAN JOURNAL OF DIGESTIVE DISEASES | 1978年 / 23卷 / 10期

关键词：

D O I：

10.1007/BF01072460

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

To determine whether a sensitization to ethanol metabolites occurs in alcoholic liver disease, reactivity of lymphocytes to nontoxic amounts of acetaldehyde was studied by direct elaboration of migration inhibitory factor (MIF) production. Alcoholics (18) with various degrees of biopsy-proven liver damage showed increased MIF production in response to acetaldehyde. The mean value of the group differed significantly from 15 healthy controls, 15 subjects with nonalcoholic liver disease and 15 alcoholics without liver involvement (P < 0.001, P < 0.001, P < 0.02, respectively). Among the alcoholics with liver disease, 9 individuals (50%) with histological signs of advanced alcoholic hepatitis showed the highest percentage of inhibition of migration. The value differed significantly from the remaining patients with lesser degrees of hyaline necrosis in liver biopsies (P < 0.005). Acetaldehyde is apparently involved in the pathogenesis of alcoholic hepatitis. Clinically, this test might facilitate the selection of patients with alcoholic hyaline necrosis.

引用

页码：883 / 886

页数：4