CLINICAL PHARMACOKINETICS OF IFOSFAMIDE IN COMBINATION WITH N-ACETYLCYSTEINE

被引：6

作者：

BENVENUTO, JA ^{[1
]}

AYELE, W ^{[1
]}

LEGHA, SS ^{[1
]}

RABER, MN ^{[1
]}

NICAISE, C ^{[1
]}

NEWMAN, RA ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,WALLINGFORD,CT 06492

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 01期

关键词：

IFOSFAMIDE; N-ACETYLCYSTEINE; PHARMACOKINETICS;

D O I：

10.1097/00001813-199202000-00004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pharmacokinetics of ifosfamide were studied in 20 patients with soft tissue and bone sarcomas. Drug was administered as a 30-60 min i.v. infusion at 1.2 or 2.0 mg/m2/day for five consecutive days. Some patients also received 1.5 g/m2 of N-acetylcysteine (NAC) administered 3 times per day during the course of therapy. NAC had no effect on ifosfamide pharmacokinetics. There were significant differences in plasma half-life, area under the concentration-time curve and plasma clearance on day 1 versus day 5 of ifosfamide administration. Myelosuppression and granulocytopenia correlated better with day 1 versus day 5 ifosfamide pharmacokinetics suggesting that the alteration of ifosfamide pharmacology with multiple dosing has a significant effect on drug activity.

引用

页码：19 / 23

页数：5