DEVELOPMENT OF AN EFFICIENT OLIGONUCLEOTIDE DERIVATIZATION PROTOCOL

被引：15

作者：

GMEINER, WH

LUO, W

PON, RT

LOWN, JW

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

[2] UNIV CALGARY,REG DNA SYNTH LAB,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)81111-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient procedure is presented for the introduction of a 6-N-(2-cholesteroloxycarboaminoethyl)-or 6-N-[2-(9-fluorenylmethoxycarboamino)ethyl] moieties into adenosine, which is compatible with solid phase incorporation into antisense oligodeoxyribonucleotides and has the further advantage of lack of diastereomer formation.

引用

收藏

页码：487 / 490

页数：4

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