PERFUSION AND DIFFUSION MR-IMAGING OF THROMBOEMBOLIC STROKE

被引：46

作者：

DECRESPIGNY, AJ

TSUURA, M

MOSELEY, ME

KUCHARCZYK, J

机构：

[1] Department of Radiology., University of California, San Francisco, San Francisco, California, 94143, Box 0628

[2] Department of Neurological Surgery, Wakayama Medical College, Wakayama City

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 05期

关键词：

BRAIN; ISCHEMIA; PERFUSION; MR; CONTRAST ENHANCEMENT; DIFFUSION STUDIES; FUNCTIONAL STUDIES; PERFUSION STUDIES; VASCULAR STUDIES;

D O I：

10.1002/jmri.1880030510

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A carotid embolic stroke model in rats was studied with a combination of diffusion- and perfusion-sensitive magnetic resonance (MR) imaging at 4.7 T. Capillary blood deoxygenation changes were monitored during formation of focal ischemia by acquiring multisection magnetic susceptibility-weighted echo-planar images. A signal intensity decrease of 7% +/- 3 in ischemic brain (1% +/- 2 in normal brain) was attributable to a T2* decrease due to increased blood deoxygenation, which correlated well with subsequently measured decreases in the apparent diffusion coefficient. The same multisection methods were used to track the first-pass transit of a bolus of dysprosium-DTPA-BMA [diethylenetriaminepentnacetic acid-bis(methylamide)] to assess relative tissue perfusion before and after stroke and after treatment with a thrombolytic agent. Analysis of contrast agent transit profiles suggested a total perfusion deficit in ischemic tissue and essentially unchanged perfusion in normal brain tissue after stroke.

引用

页码：746 / 754

页数：9

共 18 条

[1]

Le Bihan D, Breton E, Lallemand D, Et al., MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders, Radiology, 161, pp. 401-416, (1986)

[2]

Moseley ME, Cohen Y, Mintorovitch J, Et al., Early detection of stroke by diffusion MRI, Magn Reson Med, 14, pp. 330-343, (1990)

[3]

Moseley ME, Kucharczyk J, Mintorovitch J, Et al., Diffusion weighted imaging of acute stroke, AJNR, 11, pp. 423-429, (1990)

[4]

Bose B, Jones SC, Lorig R, Friel HT, Weinstein M, Little J, Evolving focal cerebral ischemia in cats: spatial correlation of nuclear magnetic resonance imaging, cerebral blood flow, tet‐razolium staining and histopathology, Stroke, 19, pp. 28-37, (1988)

[5]

Barone FC, Clark RK, Feuerstein G, Lenkinski RE, Sarkar SK, Quantitative comparison of magnetic resonance imaging (MRI) and histologic analyses of focal ischemic damage in the rat, Brain Res Bull, 26, pp. 285-291, (1991)

[6]

Rosen BR, Belliveau JW, Vevea JM, Brady T, Perfusion imaging with NMR contrast agents, Magn Reson Med, 14, pp. 249-265, (1990)

[7]

Villringer A, Rosen BR, Belliveau JW, Et al., Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects, Magnetic Resonance in Medicine, 6, pp. 164-174, (1988)

[8]

Ogawa S, Lee TM, Nayak AS, Glynn P, Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields, Magn Reson Med, 14, pp. 68-78, (1990)

[9]

Turner R, Le Bihan D, Moonen CTW, Despres D, Frank J, Echo‐planar time course MRI of cat brain oxygenation changes, Magn Reson Med, 22, pp. 159-166, (1991)

[10]

Kwong KK, Belliveau JW, Chesler DA, Et al., Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation, Proc Natl Acad Sci U S A, 89, pp. 5675-5679, (1992)

← 1 2 →