PERFUSION AND DIFFUSION MR-IMAGING OF THROMBOEMBOLIC STROKE

被引：46

作者：

DECRESPIGNY, AJ

TSUURA, M

MOSELEY, ME

KUCHARCZYK, J

机构：

[1] Department of Radiology., University of California, San Francisco, San Francisco, California, 94143, Box 0628

[2] Department of Neurological Surgery, Wakayama Medical College, Wakayama City

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 05期

关键词：

BRAIN; ISCHEMIA; PERFUSION; MR; CONTRAST ENHANCEMENT; DIFFUSION STUDIES; FUNCTIONAL STUDIES; PERFUSION STUDIES; VASCULAR STUDIES;

D O I：

10.1002/jmri.1880030510

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A carotid embolic stroke model in rats was studied with a combination of diffusion- and perfusion-sensitive magnetic resonance (MR) imaging at 4.7 T. Capillary blood deoxygenation changes were monitored during formation of focal ischemia by acquiring multisection magnetic susceptibility-weighted echo-planar images. A signal intensity decrease of 7% +/- 3 in ischemic brain (1% +/- 2 in normal brain) was attributable to a T2* decrease due to increased blood deoxygenation, which correlated well with subsequently measured decreases in the apparent diffusion coefficient. The same multisection methods were used to track the first-pass transit of a bolus of dysprosium-DTPA-BMA [diethylenetriaminepentnacetic acid-bis(methylamide)] to assess relative tissue perfusion before and after stroke and after treatment with a thrombolytic agent. Analysis of contrast agent transit profiles suggested a total perfusion deficit in ischemic tissue and essentially unchanged perfusion in normal brain tissue after stroke.

引用

页码：746 / 754

页数：9

共 18 条

[11]

Thulborn KR, Waterton JC, Matthews PM, Radda GK, Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field, Biochim Biophys Acta, 714, pp. 265-270, (1982)

[12]

Turner R, Bizzi A, Despres D, Alger J, Di Chiro G, Dynamic gradient‐echo echo‐planar imaging and deoxygenation in reversible global ischemia of cat brain. Works in progress (abstr), Book of abstracts: Society of Magnetic Resonance in Medicine 1991, (1991)

[13]

de Crespigny AJ, Wendland M, Derugin N, Kozniewska E, Moseley ME, Real‐time observation of transient ischemia and hyperemia in cat brain, Magn Reson Med, 27, pp. 391-397, (1993)

[14]

Kudo M, Aoyama A, Ichimori S, Fukunaga N, An animal model of cerebral infarction: homologous blood clot emboli in rats, Stroke, 13, pp. 505-508, (1982)

[15]

Kaneko D, Nakamura N, Ogawa T, Cerebral infarction in rats using homologous blood emboli: development of a new experimental model, Stroke, 16, pp. 76-84, (1985)

[16]

Stejskal EO, Tanner JE, Spin diffusion measurements: spinechoes in the presence of a time‐dependent field gradient, J Chem Phys, 42, pp. 288-292, (1965)

[17]

Howseman AM, Stehling MK, Chapman B, Et al., Improvements in snap‐shot nuclear magnetic resonance imaging, Br J Radiol, 61, pp. 822-828, (1988)

[18]

Belliveau JW, Rosen BR, Kantor HL, Et al., Functional cerebral imaging by susceptibility‐contrast NMR, Magn Reson Med, 14, pp. 538-546, (1990)

← 1 2 →