USE OF EX-VIVO BINDING TO ESTIMATE BRAIN PENETRATION AND CENTRAL ACTIVITY OF CCK-B ANTAGONISTS

被引：5

作者：

PATEL, S

CHAPMAN, KL

SMITH, AJ

HEALD, A

FREEDMAN, SB

机构：

[1] Merck Sharp & Dohme Research Laboratories, Department of Biochemistry Neuroscience Research, Research Centre, Harlow, Essex, Terlings Park Eastwick Road

来源：

CHOLECYSTOKININ | 1994年 / 713卷

关键词：

D O I：

10.1111/j.1749-6632.1994.tb44093.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：360 / 363

页数：4

共 5 条

[1] BERTRAND P, 1993, NEUROPEPTIDES, V24, P128
[2] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST
CHANG, RSL
LOTTI, VJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) : 4923 - 4926
[3] A 2ND GENERATION OF NONPEPTIDE CHOLECYSTOKININ RECEPTOR ANTAGONISTS AND THEIR POSSIBLE THERAPEUTIC POTENTIAL
FREEDMAN, SB
PATEL, S
SMITH, AJ
CHAPMAN, K
FLETCHER, A
KEMP, JA
MARSHALL, GR
HARGREAVES, RJ
SCHOLEY, K
MELLIN, EC
DIPARDO, RM
BOCK, MG
FREIDINGER, RM
[J]. CHOLECYSTOKININ, 1994, 713 : 312 - 318
[4] DIRECT MEASUREMENT OF MUSCARINIC AGENTS IN THE CENTRAL-NERVOUS-SYSTEM OF MICE USING EXVIVO BINDING
FREEDMAN, SB
HARLEY, EA
PATEL, S
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 174 (2-3) : 253 - 260
[5] DEVELOPMENT OF A CLASS OF SELECTIVE CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONISTS HAVING POTENT ANXIOLYTIC ACTIVITY
HUGHES, J
BODEN, P
COSTALL, B
DOMENEY, A
KELLY, E
HORWELL, DC
HUNTER, JC
PINNOCK, RD
WOODRUFF, GN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6728 - 6732

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