STUDIES ON SIOMYCIN .V. DERIVATIVES OF SIOMYCIN A PREPARED WITH THIOLCARBOXYLIC ACID

Derivatives of siomycin A were prepared by reaction with thiolcarboxylic acids such as thioglycolic acid or thiomalic acid. Sodium salts of the derivatives were remarkably soluble in water, while the parent siomycin A was quite insoluble. These “soluble derivatives” of the antibiotic were still active against many Gram-positive bacteria, although the activities were approximately one fifth of that of siomycin A. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.