ASSESSMENT OF ACETYLCHOLINE AS AN OPTIC-NERVE NEUROTRANSMITTER IN BUFO-MARINUS

被引：22

作者：

OSWALD, RE

SCHMIDT, DE

FREEMAN, JA

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,SCH MED,DEPT ANAT,NASHVILLE,TN 37232

来源：

NEUROSCIENCE | 1979年 / 4卷 / 08期

关键词：

D O I：

10.1016/0306-4522(79)90194-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The optic nerve and optic tectum of the marine toad, Bufo marinus, contain significant levels of acetylcholine as measured by gas chromatography-mass spectroscopy and significant activities of the enzymes choline acetyltransferase and acelylcholinesterase. Following eye enucleation. acetylcholine levels and the activities of these two enzymes fall in the denervated tectum. The decrease in acetylcholinesterase activity was shown histochemically to occur in tectal layers containing class II and class IV retinal ganglion cell terminals. These studies, in conjunction with previous biochemical and physiological experiments, provide additional evidence for the role of acetylcholine as an optic nerve neurotransmitter in the toad. © 1979.

引用

页码：1129 / &

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