CAPSAICIN SELECTIVELY REDUCES AIRWAY RESPONSES TO HISTAMINE, SUBSTANCE-P AND VAGAL-STIMULATION

被引：26

作者：

BIGGS, DF ^{[1
]}

LADENIUS, RC ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC PHARM & PHARMACEUT SCI,EDMONTON T6G 2N8,ALBERTA,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 01期

关键词：

Airway responsiveness; Capsaicin; Histamine; Methacholine; Substance P; Vagal stimulation;

D O I：

10.1016/0014-2999(90)90148-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Airway responsiveness to histamine, substance P, methacholine and bilateral electrical vagal stimulation was assessed in capsaicin-treated and control guinea pigs. In animals treated with capsaicin (50 mg/kg s.c.) 7 days before experiments, airway responsiveness to histamine, substance P and vagal stimulation was significantly reduced but responsiveness to methacholine was unchanged. The findings suggest that histamine and substance P, but not methacholine, require capsaicin-sensitive sensory afferent nerves for part of their actions. © 1990.

引用

页码：29 / 33

页数：5

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