UNUSUAL FEATURES OF GABA RESPONSES IN LAYERS-IV-V NEURONS OF NEOCORTEX

被引：8

作者：

ELBEHEIRY, H ^{[1
]}

PUIL, E ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT ANESTHESIOL,VANCOUVER V6T 1W5,BC,CANADA

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 01期

基金：

英国医学研究理事会;

关键词：

Dendrite; Epileptic; GABA depolarization; GABA hyperpolarization; Neocortex; Perikarya;

D O I：

10.1016/0304-3940(90)90761-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Perikaryal application of GABA produced a hyperpolarization and increased the input conductance in neurons of layers IV-V of neocortex (guinea pig). This response faded during brief applications and had a long duration when the application period was increased from 4 s to > 10 s. The sensitivity of the first response to blockade by the selective antagonist, bicuculline, indicated a mediation by γ-aminobutyric acid-A (GABAA) receptors. The longer duration response was mimicked to some extent by the GABAB agonist, baclofen. Dendritic application of GABA induced a depolarization and a conductance increase - a response which was not particularly sensitive to antagonism by bicuculline. The depolarizing response also did not have a clearly defined reversal potential and may be a consequence of complex changes in membrane conductance, possibly for Cl and Ca or Na. Fading in both types of responses may result from a concomitant postsynaptic activation of a Cl conductance with Na-dependent GABA uptake. © 1990.

引用

页码：83 / 85

页数：3