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THE USE OF MICROWAVE-OVEN FOR THE RAPID HYDROLYSIS OF BILE-ACID METHYL-ESTERS

被引：17
作者：
DAYAL, B
SALEN, G
DAYAL, V
机构：
[1] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT MED,NEWARK,NJ 07103
[2] ORTHO DIAGNOST SYST INC,HEMOSTASIS RES & DEV,RARITAN,NJ 08869
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1991年 / 59卷 / 01期
关键词：
BILE ACID METHYL ESTERS; MICROWAVE OVEN;
D O I：
10.1016/0009-3084(91)90068-M
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An efficient and convenient procedure for the hydrolysis of bile acid methyl esters is described. This is achieved by the addition of aqueous lithium hydroxide in methanol/dioxane/tetrahydrofuran (or dimethylformamide) in the microwave oven. Under these conditions the formates as well as the acetate derivatives prepared under microwave irradiation conditions were also hydrolyzed, and the desired bile acids were isolated in 86-94% yield. All these reactions were completed in the microwave oven within 45-60 s.
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页码：97 / 103
页数：7
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