BETA-FUNALTREXAMINE BLOCKADE OF OPIOID-INDUCED INHIBITION OF SOMATOSTATIN SECRETION FROM RAT STOMACH

被引：5

作者：

MCINTOSH, C ^{[1
]}

YAGO, V ^{[1
]}

KWOK, YN ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, DEPT PHYSIOL, 2146 HLTH SCI MALL, VANCOUVER V6T 1Z3, BC, CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期

基金：

英国医学研究理事会;

关键词：

SOMATOSTATIN SECRETION; DAGO; ([D-ALA(2); N-ME-PHE(4); GLY(5)-OL]ENKEPHALIN); BETA-FUNALTREXAMINE; MU-OPIOID RECEPTOR;

D O I：

10.1016/0014-2999(94)90663-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Opioid peptides are potent inhibitors of gastric somatostatin secretion. In the current investigation the effect of mu-opioid receptor blockade on responses to [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAGO) was studied. Gastric inhibitory polypeptide (GIP; 1 nM) -stimulated secretion of immunoreactive somatostatin was almost completely inhibited by DAGO (1 mu M). The CL-receptor antagonists, beta-funaltrexamine and naloxonazine, blocked the effect of DAGO. Pretreatment of rats with beta-funaltrexamine, 24 h prior to perfusion, reduced the percentage inhibition by DAGO from 88.6 +/- 5.2% to 50.7 +/- 9.3%. These studies support the involvement of mu-opioid inhibitory receptors in the regulation of gastric somatostatin secretion.

引用

页码：331 / 334

页数：4

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