IONIZING-RADIATIONS FROM NUCLEAR ESTABLISHMENTS AND CHILDHOOD LEUKEMIAS - AN ENIGMA

被引:14
作者
EVANS, HJ
机构
[1] MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, Crewe Rd
关键词
D O I
10.1002/bies.950121108
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Gardner report, recently published in the UK, showing a correlation between incidence of childhood leukaemia and paternal exposure to ionising radiations (amongst fathers working in nuclear power plants) has added a new element to debates about both the risk factors in nuclear power plants and the relationships between ionising radiations and leukaemogenesis. The epidemiologic and genetic evidence concerning leukaemias is reviewed here and it is concluded that the leukaemogenic agent, whose existence is indicated in the Gardner report, is unlikely to be paternal radiation dose per se but rather exposure to another factor that is correlated with paternal radiation dose received. Copyright © 1990 Cambridge University Press
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页码:541 / 549
页数:9
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共 77 条
[51]  
Monson R.R., 1984, RAD CARCINOGENESIS E, P97
[52]  
NEEL NV, 1990, AM J HUM GENET, V46, P1053
[53]   GENETIC IMPRINTING SUGGESTED BY MATERNAL HETERODISOMY IN NONDELETION PRADER-WILLI SYNDROME [J].
NICHOLLS, RD ;
KNOLL, JHM ;
BUTLER, MG ;
KARAM, S ;
LALANDE, M .
NATURE, 1989, 342 (6247) :281-285
[54]   X-RAY-INDUCED AND CHEMICALLY-INDUCED GERM-LINE MUTATION CAUSING PHENOTYPICAL ANOMALIES IN MICE [J].
NOMURA, T .
MUTATION RESEARCH, 1988, 198 (02) :309-320
[55]   PARENTAL EXPOSURE TO X-RAYS AND CHEMICALS INDUCES HERITABLE TUMORS AND ANOMALIES IN MICE [J].
NOMURA, T .
NATURE, 1982, 296 (5857) :575-577
[56]   CHROMOSOMAL TRANSLOCATION-T(1-19) RESULTS IN SYNTHESIS OF A HOMEOBOX FUSION MESSENGER-RNA THAT CODES FOR A POTENTIAL CHIMERIC TRANSCRIPTION FACTOR [J].
NOURSE, J ;
MELLENTIN, JD ;
GALILI, N ;
WILKINSON, J ;
STANBRIDGE, E ;
SMITH, SD ;
CLEARY, ML .
CELL, 1990, 60 (04) :535-545
[57]  
OHN OH, 1990, CELL, V60, P991
[58]  
ONIONS DE, 1987, CANCER SURV, V6, P161
[59]   CHROMOSOMAL-ABNORMALITIES IN LYMPHOID TUMORS - MECHANISM AND ROLE IN TUMOR PATHOGENESIS [J].
RABBITTS, TH ;
BOEHM, T ;
MENGLEGAW, L .
TRENDS IN GENETICS, 1988, 4 (11) :300-304
[60]  
REIK W, 1989, HUM GENET DIS, V5, P331