ROLE OF GLYCOLYTIC FLUX IN EFFECT OF GLUCOSE IN DECREASING FATTY-ACID-INDUCED RELEASE OF LACTATE-DEHYDROGENASE FROM ISOLATED CORONARY LIGATED RAT-HEART

被引：49

作者：

OPIE, LH ^{[1
]}

BRICKNELL, OL ^{[1
]}

机构：

[1] UNIV CAPE TOWN, CAPE TOWN 7900, SOUTH AFRICA

来源：

CARDIOVASCULAR RESEARCH | 1979年 / 13卷 / 12期

关键词：

D O I：

10.1093/cvr/13.12.693

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary: The mechanisms whereby glucose reduces fatty acid-induced release of enzyme from the coronary-ligated isolated perfused working rat heart are investigated. Alterations in the tissue contents of ATP, phosphocreatine, or glycogen could be excluded as possible mechanisms for the beneficial effect of glucose in this system. Provision of glycolytic ATP from increased glycolytic flux may be one important factor.

引用

收藏

页码：693 / 702

页数：10

相关论文

共 38 条

[31] ENZYME RELEASE RESULTING FROM TOTAL ISCHEMIA AND REPERFUSION IN ISOLATED, PERFUSED GUINEA-PIG HEART [J].

SAKAI, K ;

GEBHARD, MM ;

SPIECKERMANN, PG ;

BRETSCHNEIDER, HJ .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1975, 7 (11) :827-840

[32] MYOCARDIAL UPTAKE AND FRACTIONAL DISTRIBUTION OF PALMITATE-1-C14 BY ISCHEMIC DOG HEART [J].

SCHEUER, J ;

BRACHFELD, N .

METABOLISM, 1966, 15 (10) :945-+

[33] PROTECTIVE ROLE OF INCREASED MYOCARDIAL GLYCOGEN STORES IN CARDIAC ANOXIA IN RAT [J].

SCHEUER, J ;

STEZOSKI, SW .

CIRCULATION RESEARCH, 1970, 27 (05) :835-&

[34] ACYL-COA INHIBITION OF ADENINE-NUCLEOTIDE TRANSLOCATION IN ISCHEMIC MYOCARDIUM [J].

SHUG, AL ;

SHRAGO, E ;

BITTAR, N ;

FOLTS, JD ;

KOKE, JR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1975, 228 (03) :689-692

[35] REGIONAL BLOOD-FLOW, CONTRACTILITY AND METABOLISM IN EARLY MYOCARDIAL-INFARCTION [J].

WEISHAAR, R ;

SARMA, JSM ;

MARUYAMA, Y ;

FISCHER, R ;

BING, RJ .

CARDIOLOGY, 1977, 62 (01) :2-20

[36] ROLE OF ANAEROBIC METABOLISM IN PRESERVATION OF FUNCTIONAL CAPACITY AND STRUCTURE OF ANOXIC MYOCARDIUM [J].

WEISSLER, AM ;

KRUGER, FA ;

BABA, N ;

SCARPELL.DG ;

LEIGHTON, RF ;

GALLIMOR.JK .

JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (02) :403-+

[37] EFFECT OF ATP ON RELEASE OF INTRACELLULAR ENZYMES FROM DAMAGED CELLS [J].

WILKINSON, JH ;

ROBINSON, JM .

NATURE, 1974, 249 (5458) :662-663

[38]

1970, SCI TABLES, P172

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