ENANTIOSELECTIVE RADICAL-MEDIATED REDUCTION OF ALPHA-IODOLACTONE USING TRIBUTYLTIN HYDRIDE IN THE PRESENCE OF A CHIRAL AMINE AND A LEWIS-ACID

被引：63

作者：

MURAKATA, M ^{[1
]}

TSUTSUI, H ^{[1
]}

HOSHINO, O ^{[1
]}

机构：

[1] SCI UNIV TOKYO,FAC PHARMACEUT SCI,SHINJUKU KU,TOKYO 162,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 04期

关键词：

D O I：

10.1039/c39950000481

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective radical-mediated reduction of alpha-methoxymethyl-alpha-iododihydrocoumarin 1 using tributyltin hydride is realized in up to 62% enantiomeric excess (e,e.) (88% chemical yield) by combination of chiral diamine 2 and magnesium iodide.

引用

页码：481 / 482

页数：2

共 15 条

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