PRODUCTION OF FREE RADICALS IN REDUCED GLUTATHIONE AND PENICILLAMINE BY THERMAL HYDROGEN ATOMS AND X-RADIATION

被引：6

作者：

COPELAND, ES

机构：

[1] Department of Biophysics, Roswell Park Memorial Institute, Buffalo, NY

[2] Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington D.C.

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/09553006914551131

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Electron-spin-resonance spectroscopy was used to observe the free radicals induced in reduced penicillamine and reduced glutathione both by x-irradiation and bombardment by thermal hydrogen atoms. X-irradiation at 77°K indicated that free radicals were initially located on αcarbon atoms in both molecules. When irradiated penicillamine was gradually warmed, E.S.R. centres were completely transferred to sulphur at about 200°K. In the case of irradiated glutathione, however, 8 days at room temperature were required for transfer of E.S.R. centres to sulphur. Hydrogen-atom bombardment resulted in the formation of the organo-sulphur radical in both compounds without evidence of hydrogen abstraction from αcarbon atoms. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：113 / &

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