C-FOS MESSENGER-RNA IN MOUSE-BRAIN AFTER MPTP TREATMENT

被引：12

作者：

DUCHEMIN, AM

GUDEHITHLU, KP

NEFF, NH

HADJICONSTANTINOU, M

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT PHARMACOL, COLUMBUS, OH 43210 USA

[2] OHIO STATE UNIV, COLL MED, DEPT PSYCHIAT, COLUMBUS, OH 43210 USA

[3] OHIO STATE UNIV, COLL MED, OHIO STATE PROGRAM, NEUROSCI PROGRAM, COLUMBUS, OH 43210 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 1992年 / 20卷 / 03期

关键词：

D O I：

10.1016/0197-0186(92)90042-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neurotoxin, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a transient increase of mRNA for the immediate-early gene c-fos in the mouse brain. The c-fos mRNA level is MPTP dose-dependent and is evident in all brain regions tested including striatum, hypothalamus, cortex, hippocampus, cerebellum and midbrain. There are regional differences in the time-course for the rise of c-fos mRNA. Pretreatment with deprenyl, a selective monoamine oxidase B inhibitor, pargyline, a nonselective monoamine oxidase inhibitor, or mazindol, a dopamine uptake transport inhibitor, does not prevent the c-fos mRNA increase, suggesting that the elevation is due to the action of MPTP and not its neurotoxic metabolite MPP+.

引用

页码：281 / 287

页数：7

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