EXPRESSION OF DRG DURING MURINE EMBRYONIC-DEVELOPMENT

被引：40

作者：

SAZUKA, T

KINOSHITA, M

TOMOOKA, Y

IKAWA, Y

NODA, M

KUMAR, S

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT VIRAL ONCOL,KAMI IKEBUKURO,TOKYO 170,JAPAN

[2] RIKEN,TSUKUBA LIFE SCI CTR,MOLEC ONCOL LAB,TSUKUBA,IBARAKI 305,JAPAN

[3] UNIV TSUKUBA,INST BIOL SCI,TSUKUBA,IBARAKI 305,JAPAN

[4] RIKEN,TSUKUBA LIFE SCI CTR,CELL BIOL LAB,TSUKUBA,IBARAKI 305,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 189卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0006-291X(92)91568-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We had previously characterised a cDNA which encodes a novel GTP-binding protein DRG. The expression of drg gene is down-regulated during the embryonic development of murine central nervous system. Further analysis of drg mRNA and protein in adult mouse tissues and various cell lines of different origins indicated that it is expressed widely, albeit at low and variable levels. In situ hybridisation analysis of mRNA expression in sections of mouse embryos indicated that drg is expressed strongly in various embryonic tissues. The expression of drg mRNA is greatly reduced in newborn animals. At cellular level, DRG protein can be detected in the cytoplasm. These observations suggest that DRG may play multiple roles in development and normal cell metabolism. © 1992.

引用

页码：371 / 377

页数：7

共 15 条

[1] A UNIVERSAL RETROVIRAL VECTOR FOR EFFICIENT CONSTITUTIVE EXPRESSION OF EXOGENOUS GENES [J].