LOCALIZATION OF TARGETS FOR ANTIULCER DRUGS IN CELLS OF THE IMMUNE-SYSTEM

被引：82

作者：

MEZEY, E

PALKOVITS, M

机构：

[1] NIMH,CELL BIOL LAB,BETHESDA,MD 20892

[2] NINCDS,BETHESDA,MD 20892

来源：

SCIENCE | 1992年 / 258卷 / 5088期

关键词：

D O I：

10.1126/science.1333642

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gastric mucosa consists of the epithelium, which lines the lumen, the lamina propria, and the muscularis mucosae. The targets of drugs used to treat stomach and duodenal ulcers are thought to be the acid-secreting parietal cells of the epithelium. However, immune cells in the lamina propria are the only cells that showed detectable messenger RNAs for histamine, muscarinic, gastrin, and dopamine receptors by in situ hybridization histochemistry. None of the epithelial cells expressed any of these messenger RNAs. Thus, the targets of antiulcer drugs seem to be cells of the immune system in the gut and not parietal cells, as generally believed. This conclusion may revise the thinking about ulcer formation and may shed light on the etiology of such chronic small intestinal diseases as Crohn's disease.

引用

页码：1662 / 1665

页数：4

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