BENZODIAZEPINES AND THEIR SOLVENTS INFLUENCE NEUTROPHIL GRANULOCYTE FUNCTION

被引：24

作者：

WEISS, M ^{[1
]}

MIROW, N ^{[1
]}

BIRKHAHN, A ^{[1
]}

SCHNEIDER, M ^{[1
]}

WERNET, P ^{[1
]}

机构：

[1] UNIV DUSSELDORF, DEPT BLOOD COAGULAT & TRANSFUS MED, W-4000 DUSSELDORF 1, GERMANY

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1993年 / 70卷 / 03期

关键词：

BLOOD; GRANULOCYTE FUNCTION; HYPNOTICS; BENZODIAZEPINES; DIAZEPAM; MIDAZOLAM; MEASUREMENT TECHNIQUES; CHEMILUMINESCENCE;

D O I：

10.1093/bja/70.3.317

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have examined the effects of commercially available preparations and drug-free solvents of diazepam (Valium, Diazepam-Lipuro) and midazolam (Dormicum) by N-formylmethionyl-leucyl-phenylalanine (FMLP)- and zymosan-induced polymorphonuclear cell (PMN) chemiluminescence and in a cell- free chemiluminescence system. In the case of Valium, drug-free solvent and diazepam suppressed PMN chemiluminescence. With Diazepam-Lipuro, the solvent stimulated and diazepam inhibited PMN chemiluminescence. With midazolam (Dormicum), only the active drug depressed PMN chemiluminescence. FMLP-induced PMN chemiluminescence was depressed 10-100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence.

引用

页码：317 / 321

页数：5

共 30 条

[1] EFFECTS OF BIFONAZOLE, FLUCONAZOLE, ITRACONAZOLE, AND TERBINAFINE ON THE CHEMILUMINESCENCE RESPONSE OF IMMUNE CELLS [J].

ABRUZZO, GK ;

FROMTLING, RA ;

TURNBULL, TA ;

GILTINAN, DM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1987, 20 (01) :61-68

[2] OXYGEN-DEPENDENT MICROBIAL KILLING BY PHAGOCYTES .2. [J].

BABIOR, BM .

NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (13) :721-725

[3]

BADWEY JA, 1986, CURR TOP CELL REGUL, V28, P183

[4]

BECKER EL, 1986, FASEB J, V45, P2151

[5]

BRUCHELT G, 1984, J CLIN CHEM CLIN BIO, V22, P1

[6] CA-2+ AND PHORBOL ESTER ACTIVATION OF PROTEIN-KINASE-C AT INTRACELLULAR CA-2+ CONCENTRATIONS AND THE EFFECT OF TMB-8 [J].

CHRISTIANSEN, NO ;

LARSEN, CS ;

JUHL, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 882 (01) :57-62

[7] PLASMA-CONCENTRATIONS AND PHARMACOKINETICS OF MIDAZOLAM DURING ANESTHESIA [J].

CREVATPISANO, P ;

DRAGNA, S ;

GRANTHIL, C ;

COASSOLO, P ;

CANO, JP ;

FRANCOIS, G .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1986, 38 (08) :578-582

[8] OPTIMAL CONDITIONS FOR SIMULTANEOUS PURIFICATION OF MONONUCLEAR AND POLYMORPHONUCLEAR LEUKOCYTES FROM HUMAN-BLOOD BY THE HYPAQUE-FICOLL METHOD [J].

FERRANTE, A ;

THONG, YH .

JOURNAL OF IMMUNOLOGICAL METHODS, 1980, 36 (02) :109-117

[9]

FULOP T, 1988, BIOCHEM INT, V17, P419

[10]

GALLIN JI, 1984, FED PROC, V43, P2732

← 1 2 3 →