BENZODIAZEPINES AND THEIR SOLVENTS INFLUENCE NEUTROPHIL GRANULOCYTE FUNCTION

被引：24

作者：

WEISS, M ^{[1
]}

MIROW, N ^{[1
]}

BIRKHAHN, A ^{[1
]}

SCHNEIDER, M ^{[1
]}

WERNET, P ^{[1
]}

机构：

[1] UNIV DUSSELDORF, DEPT BLOOD COAGULAT & TRANSFUS MED, W-4000 DUSSELDORF 1, GERMANY

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1993年 / 70卷 / 03期

关键词：

BLOOD; GRANULOCYTE FUNCTION; HYPNOTICS; BENZODIAZEPINES; DIAZEPAM; MIDAZOLAM; MEASUREMENT TECHNIQUES; CHEMILUMINESCENCE;

D O I：

10.1093/bja/70.3.317

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have examined the effects of commercially available preparations and drug-free solvents of diazepam (Valium, Diazepam-Lipuro) and midazolam (Dormicum) by N-formylmethionyl-leucyl-phenylalanine (FMLP)- and zymosan-induced polymorphonuclear cell (PMN) chemiluminescence and in a cell- free chemiluminescence system. In the case of Valium, drug-free solvent and diazepam suppressed PMN chemiluminescence. With Diazepam-Lipuro, the solvent stimulated and diazepam inhibited PMN chemiluminescence. With midazolam (Dormicum), only the active drug depressed PMN chemiluminescence. FMLP-induced PMN chemiluminescence was depressed 10-100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence.

引用

页码：317 / 321

页数：5

共 30 条

[21]

PERSSON MP, 1988, CLIN PHARMACOL THER, V43, P324

[22] DETERMINATION OF MIDAZOLAM AND 2 METABOLITES OF MIDAZOLAM IN HUMAN-PLASMA BY GAS-CHROMATOGRAPHY NEGATIVE CHEMICAL-IONIZATION MASS-SPECTROMETRY [J].

RUBIO, F ;

MIWA, BJ ;

GARLAND, WA .

JOURNAL OF CHROMATOGRAPHY, 1982, 233 (DEC) :157-165

[23]

Schulz M, 1991, Anasthesiol Intensivmed Notfallmed Schmerzther, V26, P37, DOI 10.1055/s-2007-1000534

[24] PHORBOL 12-MYRISTATE 13-ACETATE ACTIVATES RABBIT NEUTROPHILS WITHOUT AN APPARENT RISE IN THE LEVEL OF INTRACELLULAR FREE CALCIUM [J].

SHAAFI, RI ;

WHITE, JR ;

MOLSKI, TFP ;

SHEFCYK, J ;

VOLPI, M ;

NACCACHE, PH ;

FEINSTEIN, MB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 114 (02) :638-645

[25] MODEL FOR LEUKOCYTE REGULATION BY CHEMOATTRACTANT RECEPTORS - ROLES OF A GUANINE-NUCLEOTIDE REGULATORY PROTEIN AND POLYPHOSPHOINOSITIDE METABOLISM [J].

SNYDERMAN, R ;

SMITH, CD ;

VERGHESE, MW .

JOURNAL OF LEUKOCYTE BIOLOGY, 1986, 40 (06) :785-800

[26] RESPIRATORY AND CARDIOVASCULAR EFFECTS IN RELATION TO PLASMA-LEVELS OF MIDAZOLAM AND DIAZEPAM [J].

SUNZEL, M ;

PAALZOW, L ;

BERGGREN, L ;

ERIKSSON, I .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 25 (05) :561-569

[27]

TAUBER AI, 1987, BLOOD, V69, P711

[28] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY TO DETERMINE MIDAZOLAM AND FLUMAZENIL SIMULTANEOUSLY IN HUMAN PLASMA [J].

VLETTER, AA ;

BURM, AGL ;

BREIMER, LTM ;

SPIERDIJK, J .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 530 (01) :177-185

[29] DECREASED PLASMA-ALBUMIN CONCENTRATION RESULTS IN INCREASED VOLUME OF DISTRIBUTION AND DECREASED ELIMINATION OF MIDAZOLAM IN INTENSIVE-CARE PATIENTS [J].

VREE, TB ;

SHIMODA, M ;

DRIESSEN, JJ ;

GUELEN, PJM ;

JANSSEN, TJ ;

TERMOND, EFS ;

VANDALEN, R ;

HAFKENSCHEID, JCM ;

DIRKSEN, MSC .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 46 (05) :537-544

[30] THE EFFECTS OF INTRAVENOUS ANESTHETIC AGENTS ON HUMAN NEUTROPHIL CHEMI-LUMINESCENCE [J].

WHITE, IWC ;

GELB, AW ;

WEXLER, HR ;

STILLER, CR ;

KEOWN, PA .

CANADIAN ANAESTHETISTS SOCIETY JOURNAL, 1983, 30 (05) :506-511

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