ACHIRAL INTERNUCLEOSIDE LINKAGES - CH2-CH2-NH AND NH-CH2-CH2 LINKAGES

被引：17

作者：

CAULFIELD, TJ ^{[1
]}

PRASAD, CVC ^{[1
]}

PROUTY, CP ^{[1
]}

SAHA, AK ^{[1
]}

SARDARO, MP ^{[1
]}

SCHAIRER, WC ^{[1
]}

YAWMAN, A ^{[1
]}

UPSON, DA ^{[1
]}

KRUSE, LI ^{[1
]}

机构：

[1] STERLING WINTHROP INC, DIV PHARMACEUT RES, 25 GREAT VALLEY PKWY, MALVERN, PA 19355 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80761-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of CH2-CH2-NH and NH-CH2-CH2 internucleoside linkages are described. Antisense oligonucleosides containing these dimer modifications hybridized to the sense sequence. Furthermore incorporation of these backbone modifications enhanced the nuclease resistance of the antisense strand.

引用

页码：2771 / 2776

页数：6

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