STUDIES ON COMPARISON OF METABOLITES IN URINE BETWEEN DEPRENYL AND METHAMPHETAMINE ADMINISTRATION .1. METABOLITES IN MONKEY URINE

被引：4

作者：

ISHIGAMI, A

TAKAHASHI, K

SHIMAMINE, M

NAKAHARA, Y

TAKEDA, Y

机构：

[1] National Institute of Hygienic Sciences, Tokyo 158, 1-18-1, Kamiyoga, Setagaya-ku

来源：

EISEI KAGAKU-JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1990年 / 36卷 / 01期

关键词：

deprenyl; GC-MS; metabolism; methamphetamine; monkey; solid extraction; urine;

D O I：

10.1248/jhs1956.36.74

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Metabolites in the urine after administration of deprenyl and methamphetamine were compared. Determination of deprenyl, N-desmethyldeprenyl, methamphetamine, p-hydroxymethamphetamine, amphetamine and p-hydroxy amphetamine in the urine was determined by use of solid extraction, trifluoroacetylation and bis (trimethylsilyl) acetamide treatment, and gas chromatography-mass spectrometry. This method was applied to the determination of metabolites in the urine of monkey administered subcutaneously at 0.2 mg/kg of deprenyl hydrochloride or methamphetamine hydrochloride. Deprenyl and desmethyldeprenyl were detected in the urine only within 12 h after deprenyl administration. Even after their disappearance, the prolonged excretion of methamphetamine and amphetamine, metabolites of deprenyl, were found until 48 h after deprenyl administration. As a result, it was suggested that deprenyl or desmethyldeprenyl in the urine seemed to be used as a marker for the discrimination between deprenyl and methamphetamine use. However, the faster disappearance of deprenyl and desmethyldeprenyl should be taken into consideration. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：74 / 78

页数：5

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