MECHANISMS OF FRAGMENTATION OF CATIONIC PEPTIDE IONS

被引：22

作者：

ZHAO, H ^{[1
]}

ADAMS, J ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES | 1993年 / 125卷 / 2-3期

基金：

美国国家科学基金会;

关键词：

PEPTIDES; CATIONS; MECHANISMS; METAL IONS;

D O I：

10.1016/0168-1176(93)80042-D

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Fragmentation mechanisms for formation of several commonly occurring product ions in high-energy collision-induced decomposition spectra of either (M + Cat2+ - H)+ ions of peptides cationized with alkaline earth metal ions, (M + Cat+)+ ions cationized with alkali metal ions, or (M + H)+ ions are evaluated by using deuterium-labelled peptides. The different sources of hydrogen transferred in the reactions are identified. Our study supports some previously proposed mechanisms but also provides evidence for others.

引用

收藏

页码：195 / 205

页数：11

相关论文

共 15 条

[1] CHARACTERIZATION BY TANDEM MASS-SPECTROMETRY OF STRUCTURAL MODIFICATIONS IN PROTEINS [J].

BIEMANN, K ;

SCOBLE, HA .

SCIENCE, 1987, 237 (4818) :992-998

[2] CONTRIBUTIONS OF MASS-SPECTROMETRY TO PEPTIDE AND PROTEIN-STRUCTURE [J].

BIEMANN, K .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1988, 16 (1-12) :99-111

[3] MASS-SPECTROMETRIC DETERMINATION OF THE AMINO-ACID-SEQUENCE OF PEPTIDES AND PROTEINS [J].

BIEMANN, K ;

MARTIN, SA .

MASS SPECTROMETRY REVIEWS, 1987, 6 (01) :1-75

[4] GAS-PHASE INTERACTIONS OF LITHIUM IONS AND DIPEPTIDES [J].

GRESE, RP ;

GROSS, ML .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (13) :5098-5104

[5] METAL-ION PEPTIDE INTERACTIONS IN THE GAS-PHASE - A TANDEM MASS-SPECTROMETRY STUDY OF ALKALI-METAL CATIONIZED PEPTIDES [J].

GRESE, RP ;

CERNY, RL ;

GROSS, ML .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (08) :2835-2842

[6] NOVEL FRAGMENTATION PROCESS OF PEPTIDES BY COLLISION-INDUCED DECOMPOSITION IN A TANDEM MASS-SPECTROMETER - DIFFERENTIATION OF LEUCINE AND ISOLEUCINE [J].

JOHNSON, RS ;

MARTIN, SA ;

BIEMANN, K ;

STULTS, JT ;

WATSON, JT .

ANALYTICAL CHEMISTRY, 1987, 59 (21) :2621-2625

[7] COLLISION-INDUCED FRAGMENTATION OF (M+H)+IONS OF PEPTIDES - SIDE-CHAIN SPECIFIC SEQUENCE IONS [J].

JOHNSON, RS ;

MARTIN, SA ;

BIEMANN, K .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1988, 86 :137-154

[8] FRAGMENTATION STUDIES OF PEPTIDES - THE FORMATION OF Y-IONS [J].

KENNY, PTM ;

NOMOTO, K ;

ORLANDO, R .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1992, 6 (02) :95-97

[9]

Leary J. A., 1989, RAPID COMMUN MASS SP, V3, P192

[10] INVESTIGATIONS OF GAS-PHASE LITHIUM-PEPTIDE ADDUCTS - TANDEM MASS-SPECTROMETRY AND SEMIEMPIRICAL STUDIES [J].

LEARY, JA ;

ZHOU, ZG ;

OGDEN, SA ;

WILLIAMS, TD .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1990, 1 (06) :473-480