MIDKINE, A NOVEL NEUROTROPHIC FACTOR, IS PRESENT IN SENILE PLAQUES OF ALZHEIMER-DISEASE

被引：81

作者：

YASUHARA, O

MURAMATSU, H

KIM, SU

MURAMATSU, T

MARUTA, H

MCGEER, PL

机构：

[1] UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,VANCOUVER V6T 1W5,BC,CANADA

[2] KAGOSHIMA UNIV,FAC MED,DEPT BIOCHEM,KAGOSHIMA 890,JAPAN

[3] ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES,MELBOURNE TUMOR BIOL BRANCH,PARKVILLE,VIC 3050,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.1406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An affinity purified antibody specific for midkine (MK) stained senile plaques in the brain of Alzheimer disease (AD) patients. After formic acid treatment, plaque staining was dramatically enhanced, and almost all β-amyloid protein (BAP) deposits were also immunoreactive for MK. MK-immunoreactivity was not observed in normal cellular components nor in other pathological lesions including tangles in AD brain. Control brain sections were not immunoreactive for MK. The presence of MK in AD brain but not in control brain was confirmed by Western blotting. MK appears to be involved in the pathological process leading to senile plaque formation. © 1993 Academic Press.

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页码：246 / 251

页数：6

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