NEUROTENSIN CONTRACTS THE GUINEA-PIG LONGITUDINAL ILEAL SMOOTH-MUSCLE BY INDUCING ACETYLCHOLINE-RELEASE

被引：78

作者：

KITABGI, P ^{[1
]}

FREYCHET, P ^{[1
]}

机构：

[1] UNIV NICE,FAC MED,MED EXPTL LAB,F-06034 NICE,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 04期

关键词：

cholinergic mediation; Guinea-pig ileum; Longitudinal intestinal smooth muscle; Neurotensin;

D O I：

10.1016/0014-2999(79)90272-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurotensin contractd the isolated longitudinal smooth muscle strip of the guinea-pig ileum, but was only 22% as effective as histamine. Neostigmine (0.1 μM) increased the effectiveness of neurotensin 4-fold. Atropine (0.1 μM) completely inhibited the contracting effect of neurotensin measured in the presence of neostigmine, whereas hexamethonium (0.1 mM) was without effect. It is concluded that in the longitudinal smooth muscle of the guinea-pig ileum, the contracting effect of neurotensin is mediated by the release of acetylcholine from nerve endings in response to a postganglionic stimulation of cholinergic nerve fibers. © 1979.

引用

页码：403 / 406

页数：4

共 5 条

[1] BERTACCINI G, 1976, PHARMACOL REV, V28, P127
[2] NEUROTENSIN - CONTRACTILE ACTIVITY, SPECIFIC BINDING, AND LACK OF EFFECT ON CYCLIC-NUCLEOTIDES IN INTESTINAL SMOOTH-MUSCLE
KITABGI, P
FREYCHET, P
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 55 (01) : 35 - 42
[3] EFFECTS OF NEUROTENSIN ON ISOLATED INTESTINAL SMOOTH MUSCLES
KITABGI, P
FREYCHET, P
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (04) : 349 - 357
[4] ORIGIN OF ACETYLCHOLINE RELEASED FROM GUINEA-PIG INTESTINE AND LONGITUDINAL MUSCLE STRIPS
PATON, WDM
ZAR, MA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1968, 194 (01): : 13 - &
[5] ACETYLCHOLINE-RELEASING EFFECT OF GASTRIN AND RELATED POLYPEPTIDES
VIZI, ES
BERTACCINI, G
IMPICCIATORE, M
KNOLL, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1972, 17 (01) : 175 - +

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