RELATIONSHIP BETWEEN DRUG PLASMA-CONCENTRATIONS AND PSYCHOMOTOR PERFORMANCE AFTER SINGLE DOSES OF ETHANOL AND BENZODIAZEPINES

被引：27

作者：

INGUM, J ^{[1
]}

BJORKLUND, R ^{[1
]}

BJORNEBOE, A ^{[1
]}

CHRISTOPHERSEN, AS ^{[1
]}

DAHLIN, E ^{[1
]}

MORLAND, J ^{[1
]}

机构：

[1] NATL INST OCCUPAT HLTH,DEPT PHYSIOL,OSLO,NORWAY

来源：

PSYCHOPHARMACOLOGY | 1992年 / 107卷 / 01期

关键词：

DIAZEPAM; FLUNITRAZEPAM; ETHANOL; PSYCHOMOTOR PERFORMANCE; DRUG PLASMA CONCENTRATION; INTERINDIVIDUAL DIFFERENCES; DRUG SENSITIVITY;

D O I：

10.1007/BF02244959

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a placebo controlled, crossover study psychomotor effects of single doses of diazepam, 10 and 20 mg, flunitrazepam, 1 and 2 mg, as well as 0.9 g ethanol/kg body weight were investigated over a time period of 6 h in 12 healthy men. Blood samples were collected simultaneously with the test sessions to determine drug concentrations in plasma or blood. The ethanol dose caused the least performance impairment, followed by 10 mg diazepam. The most pronounced impairment was caused by 2 mg flunitrazepam, whereas 20 mg diazepam and 1 mg flunitrazepam caused intermediate impairment and were approximately equipotent on group level. Considerable interindividual differences with respect to maximal impairment following a particular drug treatment were observed, with poor correlation between individual maximal impairments and individual peak plasma concentrations of the drug. The maximal impairment in simple reaction time following the flunitrazepam treatments occurred earlier relative to the peak plasma concentration of the drug as compared to the diazepam treatments. This may indicate that acute tolerance develops differently for the two drugs.

引用

页码：11 / 17

页数：7

共 23 条

[1]

ARENDT RM, 1983, J PHARMACOL EXP THER, V227, P98

[2] PLASMA CONCENTRATIONS OF BENZODIAZEPINES [J].