PHOSPHATE-ACTIVATED GLUTAMINASE EXPRESSION DURING TUMOR-DEVELOPMENT

被引：49

作者：

ALEDO, JC ^{[1
]}

SEGURA, JA ^{[1
]}

MEDINA, MA ^{[1
]}

ALONSO, FJ ^{[1
]}

DECASTRO, IN ^{[1
]}

MARQUEZ, J ^{[1
]}

机构：

[1] UNIV MALAGA,FAC CIENCIAS,DEPT BIOQUIM & BIOL MOLEC,E-29071 MALAGA,SPAIN

来源：

FEBS LETTERS | 1994年 / 341卷 / 01期

关键词：

TUMOR GLUTAMINASE; GLUTAMINASE EXPRESSION; TUMOR DEVELOPMENT;

D O I：

10.1016/0014-5793(94)80236-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Changes in phosphate-activated glutaminase activities determined in intact cells and isolated mitochondria have been followed during mouse Ehrlich ascites carcinoma development. Glutaminase activities parallel the levels of poly(A)(+) RNAs encoding for the mitochondrial phosphate activated glutaminase. During the exponential growth phase, maximum activity was observed and the relative abundance of glutaminase mRNA significantly increased with regard to the stationary growth phase. The presented results show that tumor phosphate-activated glutaminase is subject to long-term regulation by differential gene expression.

引用

页码：39 / 42

页数：4

共 26 条

[11] Lund P, 1986, METHOD ENZYMAT AN, V8, P357
[12] Markwell M A, 1981, Methods Enzymol, V72, P296
[13] NITROGEN-METABOLISM IN TUMOR-BEARING MICE
MARQUEZ, J
SANCHEZJIMENEZ, F
MEDINA, MA
QUESADA, AR
DECASTRO, IN
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1989, 268 (02) : 667 - 675
[14] MATSUNO T, 1992, CANCER RES, V52, P1192
[15] GLUTAMINOLYSIS AND GLYCOLYSIS INTERACTIONS IN PROLIFERANT CELLS
MEDINA, MA
DECASTRO, IN
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1990, 22 (07): : 681 - 683
[16] MEDINA MA, 1992, MOL CELL BIOCHEM, V113, P1
[17] THE ROLE OF HIGH-RATES OF GLYCOLYSIS AND GLUTAMINE UTILIZATION IN RAPIDLY DIVIDING CELLS
NEWSHOLME, EA
CRABTREE, B
ARDAWI, MSM
[J]. BIOSCIENCE REPORTS, 1985, 5 (05) : 393 - 400
[18] EFFECT OF AMMONIUM-IONS ON THE AEROBIC GLYCOLYSIS IN EHRLICH ASCITES TUMOR-CELLS
OLAVARRIA, JS
CHICO, E
GIMENEZGALLEGO, G
DECASTRO, IN
[J]. BIOCHIMIE, 1981, 63 (06) : 469 - 475
[19] QUESADA AR, 1988, CANCER RES, V48, P1551
[20] PURIFICATION OF PHOSPHATE-DEPENDENT GLUTAMINASE FROM ISOLATED-MITOCHONDRIA OF EHRLICH ASCITES-TUMOR CELLS
QUESADA, AR
SANCHEZJIMENEZ, F
PEREZRODRIGUEZ, J
MARQUEZ, J
MEDINA, MA
DECASTRO, IN
[J]. BIOCHEMICAL JOURNAL, 1988, 255 (03) : 1031 - 1036

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