OSTEOGENIC PROTEIN-1 INDUCES DENDRITIC GROWTH IN RAT SYMPATHETIC NEURONS

被引:214
作者
LEIN, P
JOHNSON, M
GUO, X
RUEGER, D
HIGGINS, D
机构
[1] UNIV ARIZONA,DEPT PEDIAT,TUCSON,AZ 85724
[2] SUNY BUFFALO,DEPT PHARMACOL,BUFFALO,NY 14214
[3] CREAT BIOMOLECULES INC,HOPKINTON,MA 01748
基金
美国国家科学基金会;
关键词
D O I
10.1016/0896-6273(95)90148-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sympathetic neurons from perinatal rat pups extend only a single axon when maintained in culture in the absence of glia and serum. Exposure to recombinant osteogenic protein-1 (OP-1) selectively induces the formation of dendrites that correctly segregate and modify cytoskeletal and membrane proteins and form synaptic contacts of appropriate polarity. OP-1 requires nerve growth factor (NGF) as a cofactor, and, in the presence of optimal concentrations of NGF, OP-1-induced dendritic growth from cultured perinatal neurons is comparable to that observed in situ. Sympathetic neuroblasts that had not formed dendrites in situ also responded to OP-1 in culture, indicating that OP-l can cause de novo formation as well as regeneration of dendrites. These data imply that specific signals can regulate the development of neuronal shape and polarity.
引用
收藏
页码:597 / 605
页数:9
相关论文
共 44 条
[1]   CONTROL OF CELL PATTERN IN THE NEURAL-TUBE - REGULATION OF CELL-DIFFERENTIATION BY DORSALIN-1, A NOVEL TGF-BETA FAMILY MEMBER [J].
BASLER, K ;
EDLUND, T ;
JESSELL, TM ;
YAMADA, T .
CELL, 1993, 73 (04) :687-702
[2]   DIFFERENTIAL LOCALIZATION OF MAP-2 AND TAU IN MAMMALIAN NEURONS INSITU [J].
BINDER, LI ;
FRANKFURTER, A ;
REBHUN, LI .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 466 :145-166
[3]  
BIRREN SJ, 1993, DEVELOPMENT, V119, P597
[4]   MORPHOLOGICAL-DIFFERENTIATION OF EMBRYONIC RAT SYMPATHETIC NEURONS IN TISSUE-CULTURE .1. CONDITIONS UNDER WHICH NEURONS FORM AXONS BUT NOT DENDRITES [J].
BRUCKENSTEIN, DA ;
HIGGINS, D .
DEVELOPMENTAL BIOLOGY, 1988, 128 (02) :324-336
[5]   COLOCALIZATION OF SYNAPTOPHYSIN WITH TRANSFERRIN RECEPTORS - IMPLICATIONS FOR SYNAPTIC VESICLE BIOGENESIS [J].
CAMERON, PL ;
SUDHOF, TC ;
JAHN, R ;
DECAMILLI, P .
JOURNAL OF CELL BIOLOGY, 1991, 115 (01) :151-164
[6]  
CHAMAK B, 1987, J NEUROSCI, V7, P3163
[7]   CELL-INTERACTIONS REGULATE DENDRITIC MORPHOLOGY AND RESPONSES TO NEUROTRANSMITTERS IN EMBRYONIC CHICK SYMPATHETIC PREGANGLIONIC NEURONS INVITRO [J].
CLENDENING, B ;
HUME, RI .
JOURNAL OF NEUROSCIENCE, 1990, 10 (12) :3992-4005
[8]   NEURONAL POLARITY [J].
CRAIG, AM ;
BANKER, G .
ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 :267-310
[9]  
DEKONINCK P, 1993, J NEUROSCI, V13, P577
[10]   GLIAL HETEROGENEITY MAY DEFINE THE 3-DIMENSIONAL SHAPE OF MOUSE MESENCEPHALIC DOPAMINERGIC-NEURONS [J].
DENISDONINI, S ;
GLOWINSKI, J ;
PROCHIANTZ, A .
NATURE, 1984, 307 (5952) :641-643