CYCLOOXYGENASE PRODUCTS OF METABOLISM OF ARACHIDONIC-ACID IN MOUSE MACROPHAGES EXPOSED TO N-PHENYLLINOLEAMIDE FROM TOXIC OIL SAMPLES

被引：16

作者：

RAMIS, I

BIOQUE, G

ROSELLO, J

FELIU, E

BULBENA, O

GELPI, E

机构：

[1] CSIC, CTR INVEST & DESARROLLO, DEPT NEUROCHEM, JORGE GIRONA SALGADO 18-26, E-08034 BARCELONA, SPAIN

[2] HOSP CLIN BARCELONA, BIOL HEMATOL SERV, E-08036 BARCELONA, SPAIN

[3] CSIC, CTR INVEST & DESARROLLO, DEPT PHARMACOL & TOXICOL, E-08034 BARCELONA, SPAIN

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1990年 / 39卷 / 02期

关键词：

D O I：

10.1016/0952-3278(90)90025-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-phenyllinoleamide (NPLA), one of the major extraneous constituents of Spanish toxic oil samples, appears to enhance the cyclooxygenase metabolic pathway of arachidonic acid by peritoneal mouse macrophages. Results reported herein show an increased biosynthesis of 6-oxo-PGF1α and TXB2 by macrophages exposed to NPLA. However, light and electron microscopy failed to show cellular alterations in macrophages incubated with NPLA for two hours at 27°C. These data suggest a possible involvement of cyclooxygenase arachidonic acid metabolism in the etiopathogenesis of the Spanish Toxic Oil Syndrome. © 1990.

引用

页码：147 / 149

页数：3

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