SYNTHESIS AND REACTION OF NOVEL 5-DEAZAFLAVINS WITH AXIAL CHIRALITY AT PYRIMIDINE RING MOIETY

被引：33

作者：

KAWAMOTO, T

TOMISHIMA, M

YONEDA, F

HAYAMI, J

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

[2] KYOTO UNIV,GRAD SCH HUMAN & ENVIRONM STUDIES,SAKYO KU,KYOTO 606,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79843-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series or novel 5-deazaflavin derivatives possessing axial chirality at pyrimidine ring moiety have been prepared to investigate effects of the pyrimidine site on the stereoselective reactions between flavins and substrates. Successful optical resolution or the racemic compounds has been achieved by HPLC method on a chiral stationary phase and a diastereomer formation method. The chiral recognition ability of thc 5-deazaflavin enantiomers was investigated in a model reaction of asymmetric intercoenzyme "(net) hydride transfer" reactions.

引用

页码：3169 / 3172

页数：4

共 18 条

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