REACTION OF A SERINE-DERIVED ORGANOZINC REAGENT WITH CHLOROFORMATES AND ETHYL OXALYL CHLORIDE UNDER PALLADIUM CATALYSIS - PREPARATION OF PROTECTED (2S,6S)-4-OXO-2,6-DIAMINOPIMELIC ACID AND (2S)-4-OXOGLUTAMIC ACID

被引：15

作者：

JACKSON, RFW ^{[1
]}

WISHART, N ^{[1
]}

WYTHES, MJ ^{[1
]}

机构：

[1] PFIZER LTD, CENT RES, SANDWICH CT13 9NJ, KENT, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 21期

关键词：

D O I：

10.1039/c39920001587

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organozinc reagent 1 reacts with phenyl chloroformate under palladium catalysis to give the protected 4-oxo-2,6-diaminopimelic acid derivative 3, derived by formal displacement of both chloride and phenoxide; the symmetrical ketone 3, together with protected 4-oxoglutamic acid 10, are formed when ethyl oxalyl chloride is used as substrate.

引用

页码：1587 / 1589

页数：3

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