SATIETY EFFECTS OF CHOLECYSTOKININ IN HUMANS

被引:76
作者
LIEVERSE, RJ [1 ]
JANSEN, JBMJ [1 ]
MASCLEE, AAM [1 ]
LAMERS, CBHW [1 ]
机构
[1] UNIV NIJMEGEN HOSP,DEPT GASTROENTEROL & HEPATOL,6500 HB NIJMEGEN,NETHERLANDS
关键词
D O I
10.1016/0016-5085(94)90397-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Cholecystokinin (CCK) inhibits gastric emptying and may exert satiety effects in several species, including humans. Because the effects of physiological doses of CCK on satiety in humans is unclear, the satiety effects of CCK-33 in physiological levels in lean and obese subjects were studied. Methods: CCK-33 was infused intravenously to 32 healthy men or women (14 obese, all women; 18 lean, 4 men and 14 women) in doses that elicited plasma CCK concentrations in the physiological range. The effects of these infusions on feelings of hunger, wish to eat, fullness, and prospective feeding intentions were measured on visual analogue scales and compared with saline during a 1-hour infusion period. Results: The CCK infusions induced significant decreases in hunger feelings, wish to eat, and prospective feeding intentions (P < 0.05), whereas fullness tended to be increased (P = 0.054). No clear differences between lean and obese subjects were observed apart from a more marked decrease in fullness and increase in prospective feeding intentions during the 1-hour saline infusion in the lean group (P < 0.05). Conclusions: CCK infusion leading to physiological plasma levels significantly increases satiety in humans. © 1994.
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页码:1451 / 1454
页数:4
相关论文
共 25 条
  • [1] Blundell J E, 1987, Int J Obes, V11 Suppl 1, P9
  • [2] CLINICAL PHARMACOKINETICS OF DRUGS IN OBESITY - AN UPDATE
    CHEYMOL, G
    [J]. CLINICAL PHARMACOKINETICS, 1993, 25 (02) : 103 - 114
  • [3] RAPID DEVELOPMENT OF TOLERANCE TO THE BEHAVIORAL ACTIONS OF CHOLECYSTOKININ
    CRAWLEY, JN
    BEINFELD, MC
    [J]. NATURE, 1983, 302 (5910) : 703 - 706
  • [4] TEMPORAL RELATIONSHIPS OF CHOLECYSTOKININ RELEASE, PANCREATOBILIARY SECRETION, AND GASTRIC-EMPTYING OF A MIXED MEAL
    FRIED, M
    MAYER, EA
    JANSEN, JBMJ
    LAMERS, CBHW
    TAYLOR, IL
    BLOOM, SR
    MEYER, JH
    [J]. GASTROENTEROLOGY, 1988, 95 (05) : 1344 - 1350
  • [5] MOLECULAR-FORMS OF CHOLECYSTOKININ IN PLASMA FROM NORMAL AND GASTRECTOMIZED HUMAN-SUBJECTS FOLLOWING A FAT MEAL
    JANSEN, JBMJ
    LAMERS, CBHW
    [J]. PEPTIDES, 1987, 8 (05) : 801 - 805
  • [6] RADIOIMMUNOASSAY OF CHOLECYSTOKININ IN HUMAN-TISSUE AND PLASMA
    JANSEN, JBMJ
    LAMERS, CBHW
    [J]. CLINICA CHIMICA ACTA, 1983, 131 (03) : 305 - 316
  • [7] C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ DECREASES FOOD-INTAKE IN MAN
    KISSILEFF, HR
    PISUNYER, FX
    THORNTON, J
    SMITH, GP
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1981, 34 (02) : 154 - 160
  • [8] LIDDLE RA, 1989, GASTROENTEROL CLIN N, V18, P735
  • [9] LIEVERSE R, 1993, GASTROENTEROLOGY, V104, pA632
  • [10] EFFECTS OF A PHYSIOLOGICAL DOSE OF CHOLECYSTOKININ ON FOOD-INTAKE AND POSTPRANDIAL SATIATION IN MAN
    LIEVERSE, RJ
    JANSEN, JBMJ
    VANDEZWAN, A
    SAMSON, L
    MASCLEE, AAM
    LAMERS, CBHW
    [J]. REGULATORY PEPTIDES, 1993, 43 (1-2) : 83 - 89