HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INFLUENCES RAINBOW-TROUT ONCORHYNCHUS-MYKISS LEUKOCYTE RESPONSES

被引：73

作者：

HARDIE, LJ

CHAPPELL, LH

SECOMBES, CJ

机构：

[1] Department of Zoology, University of Aberdeen, Aberdeen

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 40卷 / 01期

关键词：

D O I：

10.1016/0165-2427(94)90016-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human recombinant tumor necrosis factor alpha (rTNFalpha) and rainbow trout macrophage activating factor (postulated gamma-interferon (gamma-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFalpha and gamma-IFN commonly synergise. Human rTNFalpha also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFalpha receptor on trout leucocytes (and possibly the TNFalpha molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.

引用

页码：73 / 84

页数：12

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