DISSEMINATED TRICHOSPORON-BEIGELII INFECTION IN PATIENTS WITH MALIGNANT DISEASES - IMMUNOHISTOCHEMICAL STUDY AND REVIEW

被引：47

作者：

TASHIRO, T ^{[1
]}

NAGAI, H ^{[1
]}

KAMBERI, P ^{[1
]}

GOTO, Y ^{[1
]}

KIKUCHI, H ^{[1
]}

NASU, M ^{[1
]}

AKIZUKI, S ^{[1
]}

机构：

[1] OITA MED UNIV,DEPT PATHOL,OITA 87955,JAPAN

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1994年 / 13卷 / 03期

关键词：

D O I：

10.1007/BF01974540

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Trichosporon beigelii is a causative agent of opportunistic infection and summer-type hypersensitivity pneumonitis in Japan. However, as the diagnosis of trichosporon beigelii infection is sometimes difficult, the actual incidence of this disease may be underestimated. Of 203 autopsy patients with malignant disease, seven (7.7 %) were diagnosed with disseminated Trichosporon beigelii infection by immunohistochemical investigation of formalin-fixed, paraffin-embedded tissue sections. Including these seven, a total of 43 patients with Trichosporon beigelii infection have been reported in Japan. The majority of them had underlying hematologic malignancies, for which they received cytotoxic chemotherapy resulting in neutropenia. This study indicates that the immunohistochemical method, which can be applied to biopsy specimens, is an excellent tool for specific diagnosis of Trichosporon beigelii infection, which is an emerging fatal mycosis in immunocompromised patients with profound neutropenia.

引用

页码：218 / 224

页数：7

共 41 条

[31]

SHIMAZU K, 1984, AM REV RESPIR DIS, V130, P407

[32] APPLICATION OF A MONOCLONAL-ANTIBODY FOR THE DETECTION OF TRICHOSPORON-BEIGELII IN PARAFFIN-EMBEDDED TISSUE-SECTIONS [J].