COOPERATIVE DOMAINS IN FIBRONECTIN

被引：21

作者：

TATUNASHVILI, LV

FILIMONOV, VV

PRIVALOV, PL

METSIS, ML

KOTELIANSKY, VE

INGHAM, KC

MEDVED, LV

机构：

[1] AMER RED CROSS, BIOMED RES & DEV, BIOCHEM LAB, ROCKVILLE, MD 20855 USA

[2] ACAD SCI USSR, INST PROT RES, PUSHCHINO, USSR

[3] ACAD MED SCI USSR, CARDIOL RES CTR, MOSCOW 109801, USSR

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1990年 / 211卷 / 01期

关键词：

D O I：

10.1016/0022-2836(90)90018-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The melting of human plasma fibronectin and its proteolytic fragments has been studied by scanning microcalorimetry to reveal co-operative structural domains in the molecule. It has been established that each of the two similar polypeptide chains of fibronectin has at least 12 structural domains, which differ in stability, size and function. Many of the domains in the N-terminal half of the polypeptide chains appear to be composed of two homologous repeat modules that co-operate to form a single co-operative unit. In the intact fibronectin molecule, the C-terminal regions of both chains seem to interact forming a stable co-operative block. © 1990.

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页码：161 / 169

页数：9

相关论文

共 45 条

[31] THERMODYNAMIC PROBLEMS OF PROTEIN-STRUCTURE [J].

PRIVALOV, PL .

ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY, 1989, 18 :47-69

[32] EARLY AND LATE CATHEPSIN D-DERIVED FRAGMENTS OF FIBRONECTIN CONTAINING THE C-TERMINAL INTERCHAIN DISULFIDE CROSS-LINK [J].

RICHTER, H ;

HORMANN, H .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1982, 363 (04) :351-364

[33] FIBRONECTIN - A MOLECULE WITH REMARKABLE STRUCTURAL AND FUNCTIONAL DIVERSITY [J].

RUOSLAHTI, E ;

PIERSCHBACHER, M ;

HAYMAN, EG ;

ENGVALL, E .

TRENDS IN BIOCHEMICAL SCIENCES, 1982, 7 (05) :188-190

[34] FIBRONECTIN AND ITS RECEPTORS [J].

RUOSLAHTI, E .

ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 :375-413

[35]

SEKIGUCHI K, 1983, J BIOL CHEM, V258, P3967

[36] COMPLETE PRIMARY STRUCTURE OF BOVINE PLASMA FIBRONECTIN [J].

SKORSTENGAARD, K ;

JENSEN, MS ;

SAHL, P ;

PETERSEN, TE ;

MAGNUSSON, S .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 161 (02) :441-453

[37] NEAR ULTRAVIOLET CIRCULAR-DICHROISM SPECTROSCOPY OF PLASMA FIBRONECTIN AND FIBRONECTIN FRAGMENTS [J].

TOONEY, NM ;

AMRANI, DL ;

HOMANDBERG, GA ;

MCDONALD, JA ;

MOSESSON, MW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (03) :1085-1091

[38] EVIDENCE FOR PREFERENTIAL PROTEOLYTIC CLEAVAGE OF ONE OF THE 2 FIBRONECTIN SUBUNITS AND FOR IMMUNOLOGICAL LOCALIZATION OF A SITE DISTINGUISHING THEM [J].

VARTIO, T ;

BARLATI, S ;

DEPETRO, G ;

MIGGIANO, V ;

STAHLI, C ;

TAKACS, B ;

VAHERI, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 135 (02) :203-207

[39] CHARACTERIZATION OF THE BINDING DOMAINS IN THE FRAGMENTS CLEAVED BY CATHEPSIN-G FROM HUMAN-PLASMA FIBRONECTIN [J].

VARTIO, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 123 (02) :223-233

[40] DISTRIBUTION OF SECONDARY STRUCTURE ALONG THE FIBRONECTIN MOLECULE [J].

VENYAMINOV, SY ;

METSIS, ML ;

CHERNOUSOV, MA ;

KOTELIANSKY, VE .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 135 (03) :485-489

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