DNA ALKYLATION BY THE HALOETHYLNITROSOUREAS - NATURE OF MODIFICATIONS PRODUCED AND THEIR ENZYMATIC REPAIR OR REMOVAL

被引：214

作者：

LUDLUM, DB

机构：

[1] Department of Pharmacology, UMass Medical School, Worcester

来源：

MUTATION RESEARCH | 1990年 / 233卷 / 1-2期

关键词：

Antitumour agents; DNA alkylation; Haloethylnitrosoureas; MNNG; antitumour activity;

D O I：

10.1016/0027-5107(90)90156-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

[No abstract available]

引用

页码：117 / 126

页数：10

共 38 条

[1] BODELL WJ, 1988, CANCER RES, V48, P4489
[2] FORMATION OF COVALENT COMPLEXES BETWEEN HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND BCNU-TREATED DEFINED LENGTH SYNTHETIC OLIGODEOXYNUCLEOTIDES
BRENT, TP
REMACK, JS
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (14) : 6779 - 6788
[3] CHEMISTRY OF NITROSOUREAS - INTERMEDIACY OF 4,5-DIHYDRO-1,2,3-OXADIAZOLE IN 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA DECOMPOSITION
BRUNDRETT, RB
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) : 1245 - 1247
[4] STRUCTURE ACTIVITY RELATIONS OF (2-CHLOROETHYL)NITROSOUREAS .2. KINETIC EVIDENCE OF A NOVEL MECHANISM FOR THE CYTOTOXICALLY IMPORTANT DNA CROSS-LINKING REACTIONS OF (2-CHLOROETHYL)NITROSOUREAS
BUCKLEY, N
BRENT, TP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (22) : 7520 - 7529
[5] A REGIOSELECTIVE MECHANISM FOR MUTAGENESIS AND ONCOGENESIS CAUSED BY ALKYLNITROSOUREA SEQUENCE-SPECIFIC DNA ALKYLATION
BUCKLEY, N
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (25) : 7918 - 7920
[6] PHOSPHOTRIESTER FORMATION BY THE HALOETHYLNITROSOUREAS AND REPAIR OF THESE LESIONS BY ESCHERICHIA-COLI BS21 EXTRACTS
CARTER, CA
KIRK, MC
LUDLUM, DB
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (12) : 5661 - 5672
[7] RELEASE OF 7-ALKYLGUANINES FROM HALOETHYLNITROSOUREA-TREATED DNA BY ESCHERICHIA-COLI 3-METHYLADENINE-DNA GLYCOSYLASE-II
CARTER, CA
HABRAKEN, Y
LUDLUM, DB
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 155 (03) : 1261 - 1265
[8] CHEMICAL BASIS FOR ANTITUMOR ACTIVITY OF CHLOROETHYLNITROSOUREAS
COLVIN, M
BRUNDRETT, RB
COWENS, W
JARDINE, I
LUDLUM, DB
[J]. BIOCHEMICAL PHARMACOLOGY, 1976, 25 (06) : 695 - 699
[9] DOLAN ME, 1986, CANCER RES, V46, P4500
[10] DNA CROSS-LINKING AND MONOADDUCT REPAIR IN NITROSOUREA-TREATED HUMAN-TUMOR CELLS
ERICKSON, LC
LAURENT, G
SHARKEY, NA
KOHN, KW
[J]. NATURE, 1980, 288 (5792) : 727 - 729

← 1 2 3 4 →