ROLE OF ALPHA1-RECEPTORS IN THE BEHAVIORAL SUPERSENSITIVITY TO D2 AGONISTS INDUCED BY CHRONIC TREATMENT WITH IMIPRAMINE

被引：8

作者：

DAQUILA, PS ^{[1
]}

COLLU, M ^{[1
]}

GESSA, GL ^{[1
]}

SERRA, G ^{[1
]}

机构：

[1] UNIV CAGLIARI, BB BRODIE DEPT NEUROSCI, VIA PORCELL 4, I-09124 CAGLIARI, ITALY

来源：

PHARMACOLOGICAL RESEARCH | 1992年 / 25卷 / 01期

关键词：

IMIPRAMINE; D2; RECEPTOR; ALPHA1-RECEPTOR; BEHAVIORAL SUPERSENSITIVITY;

D O I：

10.1016/S1043-6618(05)80068-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic treatment with imipramine increased the locomotor response to quinpirole, a selective D2 receptor agonist. This effect was blocked by minute doses of prazosin (0.1-1 mg/kg), a selective alpha1 receptor blocker, in a dose-dependent manner. Conversely, in control rats the locomotor response to quinpirole was enhanced by the stimulation of alpha1 receptors with the selective agonist St 587. The results suggest that alpha1 receptor stimulation plays a permissive role in the supersensitivity of D2 receptors following chronic treatment with imipramine. © 1992 The Italian Pharmacological Society.

引用

页码：95 / 101

页数：7

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