ADP-RIBOSYLATION OF RHO PROTEINS INHIBITS SPERM MOTILITY

被引：42

作者：

HINSCH, KD ^{[1
]}

HABERMANN, B ^{[1
]}

JUST, I ^{[1
]}

HINSCH, E ^{[1
]}

PFISTERER, S ^{[1
]}

SCHILL, WB ^{[1
]}

AKTORIES, K ^{[1
]}

机构：

[1] UNIV SAARLAND,INST PHARMAKOL & TOXIKOL,D-66421 HOMBURG,GERMANY

来源：

FEBS LETTERS | 1993年 / 334卷 / 01期

关键词：

GTP-BINDING PROTEIN; RHO PROTEIN; ADP-RIBOSYLATION; SPERM MOTILITY;

D O I：

10.1016/0014-5793(93)81674-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly homologous Rbo proteins RhoA, RhoB and RhoC are low-molecular-mass GTP-binding proteins. They are selectively ADP-ribosylated by Clostridium botulinum ADP-ribosyltransferase C3 (C3 exoenzyme). The biological function of the Rho proteins is still unclear; there is evidence that they are involved in the regulation of the filamental network of cells. Here we report that C3 exoenzyme-like toxins ADP-ribosylate small GTP-binding proteins in bovine spermatozoa and inhibit sperm motility. These findings indicate that Rho proteins which reportedly regulate the microfilament system are basically involved in sperm motility.

引用

页码：32 / 36

页数：5

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