Tractography: Where Do We Go from Here?

被引:454
作者
Jbabdi, Saad [1 ]
Johansen-Berg, Heidi [1 ]
机构
[1] Univ Oxford, FMRIB Ctr, Oxford, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
anatomical connectivity; brain connectivity; diffusion tensor imaging (DTI); high-angular-resolution diffusion imaging (HARDI); tractography;
D O I
10.1089/brain.2011.0033
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Diffusion tractography offers enormous potential for the study of human brain anatomy. However, as a method to study brain connectivity, tractography suffers from limitations, as it is indirect, inaccurate, and difficult to quantify. Despite these limitations, appropriate use of tractography can be a powerful means to address certain questions. In addition, while some of tractography's limitations are fundamental, others could be alleviated by methodological and technological advances. This article provides an overview of diffusion magnetic resonance tractography methods with a focus on how future advances might address challenges in measuring brain connectivity. Parts of this review are somewhat provocative, in the hope that they may trigger discussions possibly lacking in a field where the apparent simplicity of the methods (compared to their functional magnetic resonance imaging counterparts) can hide some fundamental issues that ultimately hinder the interpretation of findings, and cast doubt as to what tractography can really teach us about human brain anatomy.
引用
收藏
页码:169 / 183
页数:15
相关论文
共 135 条
[1]   FIBER COMPOSITION OF THE HUMAN CORPUS-CALLOSUM [J].
ABOITIZ, F ;
SCHEIBEL, AB ;
FISHER, RS ;
ZAIDEL, E .
BRAIN RESEARCH, 1992, 598 (1-2) :143-153
[2]   A Hough transform global probabilistic approach to multiple-subject diffusion MRI tractography [J].
Aganj, Iman ;
Lenglet, Christophe ;
Jahanshad, Neda ;
Yacoub, Essa ;
Harel, Noam ;
Thompson, Paul M. ;
Sapiro, Guillermo .
MEDICAL IMAGE ANALYSIS, 2011, 15 (04) :414-425
[3]   Reconstruction of the Orientation Distribution Function in Single- and Multiple-Shell q-Ball Imaging Within Constant Solid Angle [J].
Aganj, Iman ;
Lenglet, Christophe ;
Sapiro, Guillermo ;
Yacoub, Essa ;
Ugurbil, Kamil ;
Harel, Noam .
MAGNETIC RESONANCE IN MEDICINE, 2010, 64 (02) :554-566
[4]   A general framework for experiment design in diffusion MRI and its application in measuring direct tissue-microstructure features [J].
Alexander, Daniel C. .
MAGNETIC RESONANCE IN MEDICINE, 2008, 60 (02) :439-448
[5]   Optimal imaging parameters for fiber-orientation estimation in diffusion MRI [J].
Alexander, DC ;
Barker, GJ .
NEUROIMAGE, 2005, 27 (02) :357-367
[6]  
Andrews TJ, 1997, J NEUROSCI, V17, P2859
[7]   Connectivity-based parcellation of Broca's area [J].
Anwander, A. ;
Tittgemeyer, M. ;
von Cramon, D. Y. ;
Friederici, A. D. ;
Knoesche, T. R. .
CEREBRAL CORTEX, 2007, 17 (04) :816-825
[8]  
Anwander A, 2005, 11 ANN M ORG HUM BRA
[9]   New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter [J].
Assaf, Y ;
Freidlin, RZ ;
Rohde, GK ;
Basser, PJ .
MAGNETIC RESONANCE IN MEDICINE, 2004, 52 (05) :965-978
[10]   AxCaliber: A method for measuring axon diameter distribution from diffusion MRI [J].
Assaf, Yaniv ;
Blumenfeld-Katzir, Tamar ;
Yovel, Yossi ;
Basser, Peter J. .
MAGNETIC RESONANCE IN MEDICINE, 2008, 59 (06) :1347-1354