INHIBITORY EFFECTS OF LICOCHALCONE-A ISOLATED FROM GLYCYRRHIZA-INFLATA ROOT ON INFLAMMATORY EAR EDEMA AND TUMOR PROMOTION IN MICE

被引：89

作者：

SHIBATA, S

INOUE, H

IWATA, S

MA, R

YU, LJ

UEYAMA, H

TAKAYASU, J

HASEGAWA, T

TOKUDA, H

NISHINO, A

NISHINO, H

IWASHIMA, A

机构：

[1] MINOPHAGEN PHARMACEUT CO,RES LAB,ZAMA,KANAGAWA 228,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIGYO KU,KYOTO 602,JAPAN

[3] SHAANXI PROV ACAD TRADIT CHINESE MED & PHARMACOL,DEPT BIOCHEM,XIAN,PEOPLES R CHINA

[4] SHIGA UNIV MED,DEPT BIOCHEM,OTSU,SHIGA 52021,JAPAN

来源：

PLANTA MEDICA | 1991年 / 57卷 / 03期

关键词：

GLYCYRRHIZA-INFLATA; LICOCHALCONE-A; ANTIINFLAMMATORY ACTION; ANTITUMOR PROMOTING ACTION;

D O I：

10.1055/s-2006-960078

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Licochalcone A, 3-alpha, alpha-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro P-32(i)-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested.

引用

页码：221 / 224

页数：4

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