EFFECTS OF HS-142-1, A NOVEL NONPEPTIDE AND ANTAGONIST, ON DIURESIS AND NATRIURESIS INDUCED BY ACUTE VOLUME EXPANSION IN ANESTHETIZED RATS

被引：27

作者：

SANO, T

MORISHITA, Y

YAMADA, K

MATSUDA, Y

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,3-6-6 ASAHIMACHI,MACHIDA,TOKYO 194,JAPAN

[2] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,SHUNTO,SHIZUOKA 411,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91806-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study we used HS-142-1, a novel non-peptide antagonist for the atrial natriuretic peptide (ANP) receptor, to clarify the possible physiological significance of ANP in acute hypervolemia. Substantial volume expansion in anesthetized rats induced a strong diuresis and natriuresis. These renal responses were significantly blocked by HS-142-1 at a dose of 3.0 mgkg-1i.v. This observation suggests that ANP and its guanylyl cyclase-coupled receptor are, under the present conditions, physiologically involved that appears to be responsible for the renal responses in the volume homeostasis. © 1992.

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页码：824 / 829

页数：6

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