ISOLATION AND PURIFICATION OF HS-142-1, A NOVEL NONPEPTIDE ANTAGONIST FOR THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR, FROM AUREOBASIDIUM SP

被引:31
作者
MORISHITA, Y [1 ]
TAKAHASHI, M [1 ]
SANO, T [1 ]
KAWAMOTO, I [1 ]
ANDO, K [1 ]
SANO, H [1 ]
SAITOH, Y [1 ]
KASE, H [1 ]
MATSUDA, Y [1 ]
机构
[1] KYOWA HAKKO KOGYO CO LTD, TOKYO RES LABS,3-6-6 ASAHIMACHI, MACHIDA, TOKYO 194, JAPAN
来源
AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 12期
关键词
D O I
10.1080/00021369.1991.10857920
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
During the screening program for atrial natriuretic peptide (ANP) receptor ligands of microbial origin, we isolated a novel nonpeptide ANP antagonist, HS-142-1, from a culture broth of Aureobasidium pullulans var. melanigenum. Structural analysis showed that HS-142-1 was composed of 20-30 kinds of beta-1,6-glucan esterified by caproyl groups; each component had an almost equal potency. HS-142-1 inhibited [I-125]-rANP binding to its receptor in rabbit kidney cortex membranes with an IC50 of 0.3-mu-g/ml and antagonized ANP-induced cGMP production by bovine lung membranes in a dose-dependent fashion. The discovery of this nonpeptide ANP antagonist, HS-142-1, will provide a useful tool to study the physiological significance of natriuretic peptide system.
引用
收藏
页码:3017 / 3025
页数:9
相关论文
共 22 条
  • [1] ATRIAL NATRIURETIC PEPTIDE
    BAXTER, JD
    LEWICKI, JA
    GARDNER, DG
    [J]. BIO-TECHNOLOGY, 1988, 6 (05): : 529 - &
  • [2] A POTENT NONPEPTIDE CHOLECYSTOKININ ANTAGONIST SELECTIVE FOR PERIPHERAL-TISSUES ISOLATED FROM ASPERGILLUS-ALLIACEUS
    CHANG, RSL
    LOTTI, VJ
    MONAGHAN, RL
    BIRNBAUM, J
    STAPLEY, EO
    GOETZ, MA
    ALBERSSCHONBERG, G
    PATCHETT, AA
    LIESCH, JM
    HENSENS, OD
    SPRINGER, JP
    [J]. SCIENCE, 1985, 230 (4722) : 177 - 179
  • [3] CHINKERS M, 1991, J BIOL CHEM, V266, P4088
  • [4] A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR
    CHINKERS, M
    GARBERS, DL
    CHANG, MS
    LOWE, DG
    CHIN, HM
    GOEDDEL, DV
    SCHULZ, S
    [J]. NATURE, 1989, 338 (6210) : 78 - 83
  • [5] CHIU AT, 1990, J PHARMACOL EXP THER, V252, P711
  • [6] NON-PEPTIDE LIGANDS FOR PEPTIDE RECEPTORS
    FREIDINGER, RM
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (07) : 270 - 274
  • [7] FULLER F, 1988, J BIOL CHEM, V263, P9395
  • [8] HERMANIDESNIJOH.EJ, 1977, STUD MYCOL, P171
  • [9] INAGAMI T, 1989, J BIOL CHEM, V264, P3043
  • [10] PARTICIPATION OF ADENOSINE 5'-TRIPHOSPHATE IN THE ACTIVATION OF MEMBRANE-BOUND GUANYLATE-CYCLASE BY THE ATRIAL-NATRIURETIC-FACTOR
    KUROSE, H
    INAGAMI, T
    UI, M
    [J]. FEBS LETTERS, 1987, 219 (02) : 375 - 379