ISOLATION AND PURIFICATION OF HS-142-1, A NOVEL NONPEPTIDE ANTAGONIST FOR THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR, FROM AUREOBASIDIUM SP

被引：31

作者：

MORISHITA, Y ^{[1
]}

TAKAHASHI, M ^{[1
]}

SANO, T ^{[1
]}

KAWAMOTO, I ^{[1
]}

ANDO, K ^{[1
]}

SANO, H ^{[1
]}

SAITOH, Y ^{[1
]}

KASE, H ^{[1
]}

MATSUDA, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD, TOKYO RES LABS,3-6-6 ASAHIMACHI, MACHIDA, TOKYO 194, JAPAN

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 12期

关键词：

D O I：

10.1080/00021369.1991.10857920

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

During the screening program for atrial natriuretic peptide (ANP) receptor ligands of microbial origin, we isolated a novel nonpeptide ANP antagonist, HS-142-1, from a culture broth of Aureobasidium pullulans var. melanigenum. Structural analysis showed that HS-142-1 was composed of 20-30 kinds of beta-1,6-glucan esterified by caproyl groups; each component had an almost equal potency. HS-142-1 inhibited [I-125]-rANP binding to its receptor in rabbit kidney cortex membranes with an IC50 of 0.3-mu-g/ml and antagonized ANP-induced cGMP production by bovine lung membranes in a dose-dependent fashion. The discovery of this nonpeptide ANP antagonist, HS-142-1, will provide a useful tool to study the physiological significance of natriuretic peptide system.

引用

页码：3017 / 3025

页数：9

共 22 条

[1] ATRIAL NATRIURETIC PEPTIDE
BAXTER, JD
LEWICKI, JA
GARDNER, DG
[J]. BIO-TECHNOLOGY, 1988, 6 (05): : 529 - &
[2] A POTENT NONPEPTIDE CHOLECYSTOKININ ANTAGONIST SELECTIVE FOR PERIPHERAL-TISSUES ISOLATED FROM ASPERGILLUS-ALLIACEUS
CHANG, RSL
LOTTI, VJ
MONAGHAN, RL
BIRNBAUM, J
STAPLEY, EO
GOETZ, MA
ALBERSSCHONBERG, G
PATCHETT, AA
LIESCH, JM
HENSENS, OD
SPRINGER, JP
[J]. SCIENCE, 1985, 230 (4722) : 177 - 179
[3] CHINKERS M, 1991, J BIOL CHEM, V266, P4088
[4] A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR
CHINKERS, M
GARBERS, DL
CHANG, MS
LOWE, DG
CHIN, HM
GOEDDEL, DV
SCHULZ, S
[J]. NATURE, 1989, 338 (6210) : 78 - 83
[5] CHIU AT, 1990, J PHARMACOL EXP THER, V252, P711
[6] NON-PEPTIDE LIGANDS FOR PEPTIDE RECEPTORS
FREIDINGER, RM
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (07) : 270 - 274
[7] FULLER F, 1988, J BIOL CHEM, V263, P9395
[8] HERMANIDESNIJOH.EJ, 1977, STUD MYCOL, P171
[9] INAGAMI T, 1989, J BIOL CHEM, V264, P3043
[10] PARTICIPATION OF ADENOSINE 5'-TRIPHOSPHATE IN THE ACTIVATION OF MEMBRANE-BOUND GUANYLATE-CYCLASE BY THE ATRIAL-NATRIURETIC-FACTOR
KUROSE, H
INAGAMI, T
UI, M
[J]. FEBS LETTERS, 1987, 219 (02) : 375 - 379

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