INTERACTIONS BETWEEN THE METHYLATION SITES OF THE ESCHERICHIA-COLI ASPARTATE RECEPTOR-MEDIATED BY THE METHYLTRANSFERASE

被引：21

作者：

SHAPIRO, MJ ^{[1
]}

PANOMITROS, D ^{[1
]}

KOSHLAND, DE ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 02期

关键词：

D O I：

10.1074/jbc.270.2.751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations made at and near the methylation sites of the Escherichia coli aspartate receptor were found to affect the methylation rates of the remaining methylation sites. The results supported a model in which the methyltransferase enzyme contacts a residue seven amino acids to the C terminus of a site being methylated. The presence of a negatively charged residue at that position inhibits methylation, whereas a neutral residue has no effect. Methylation sites in the wild type receptor may also influence the methylation of other sites which are 7 residues away through a physical contact with the methyltransferase.

引用

页码：751 / 755

页数：5

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