MORPHINE AND NALOXONES EFFECTS ON SEXUAL-BEHAVIOR OF THE FEMALE GOLDEN-HAMSTER

被引：33

作者：

OSTROWSKI, NL ^{[1
]}

STAPLETON, JM ^{[1
]}

NOBLE, RG ^{[1
]}

REID, LD ^{[1
]}

机构：

[1] RENSSELAER POLYTECH INST,DEPT PSYCHOL,TROY,NY 12181

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Hamsters; Morphine; Naloxone; Opioids; Sexual behavior;

D O I：

10.1016/0091-3057(79)90261-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of morphine and naloxone were observed after administration to female golden hamsters (Mesocricetus auratus). Large doses of morphine, 80 mg/kg, consistently produced sedation and behavioral depression of responses to nociceptive stimuli. Smaller doses of morphine (e.g., 10 mg/kg), that produced few other behavioral changes, suppressed a measure of female sexual responding. The suppressive effects on sexual behavior were reversed by 4 mg/kg of naloxone. Morphine administered intracerebroventricularly had little effect on sexual responding, even at doses which produced other side effects. Doses of 4 and 8 mg/kg of naloxone in opioid-naive subjects did not reliably alter sexual responding up to 2 hr after administration. These observations lead to the suggestion that morphine produces effects which are incompatible with full sexual functioning in female hamsters. © 1979.

引用

页码：673 / 681

页数：9

共 41 条

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