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DIFFERENTIAL PROCESSING OF THE NEUROTENSIN NEUROMEDIN-N PRECURSOR IN THE MOUSE
被引:35
作者
:
SHAW, C
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
SHAW, C
MCKAY, D
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
MCKAY, D
JOHNSTON, CF
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
JOHNSTON, CF
HALTON, DW
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
HALTON, DW
FAIRWEATHER, I
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
FAIRWEATHER, I
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
KITABGI, P
BUCHANAN, KD
论文数:
0
引用数:
0
h-index:
0
机构:
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
BUCHANAN, KD
机构
:
[1]
QUEENS UNIV BELFAST,DEPT MED,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
[2]
QUEENS UNIV BELFAST,DEPT BIOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND
[3]
UNIV NICE,FAC SCI,CTR BIOCHEM,F-06034 NICE,FRANCE
来源
:
PEPTIDES
|
1990年
/ 11卷
/ 02期
关键词
:
Enzymatic digestion;
Mouse;
Neuromedin N;
Neurotensin;
Precursor processing;
Region-specific radioimmunoassay;
Reverse phase HPLC;
D O I
:
10.1016/0196-9781(90)90075-G
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Posttranslational processing of the neurotensin/neuromedin N (NT/NN) precursor has been investigated in mouse brain and small intestine by means of region-specific radioimmunoassays coupled to chromatographic fractionations. In brain, total NT/NN immunoreactivity measured with a common C-terminal antiserum was 15.72 pmol/g. NT measured with an N-terminal antiserum was 9.74 pmol/g and NN measured with an N-terminal antiserum was 5.98 pmol/g. In small intestine, combined NT/NN immunoreactivity was 108.55 pmol/g, consisting of 66.37 pmol/g NT but only 0.96 pmol/g NN. Gel permeation chromatography and reverse phase HPLC revealed that the large discrepancy in the NT and NN values obtained in small intestinal extracts was due to the presence of a high molecular weight, hydrophobic peptide, which was reactive only with the common C-terminally directed antiserum. Pepsinization of this generated an immunoreactive peptide with similar chromatographic characteristics to NN. In mouse intestine, NN is only partially cleaved from the common NT/NN precursor, resulting in the presence of an N-terminally extended molecular species. This novel molecular species of neuromedin N may be the physiological mediator of certain peripheral biological effects hitherto attributed to neurotensin or neuromedin N. © 1990.
引用
收藏
页码:227 / 235
页数:9
相关论文
共 21 条
[1]
CARRAWAY R, 1973, J BIOL CHEM, V248, P6854
[2]
POTENTIAL PRECURSORS TO NEUROMEDIN-N IN THE CAT AND THEIR PROCESSING BY PEPSIN
CARRAWAY, RE
论文数:
0
引用数:
0
h-index:
0
CARRAWAY, RE
MITRA, SP
论文数:
0
引用数:
0
h-index:
0
MITRA, SP
[J].
ENDOCRINOLOGY,
1987,
120
(05)
: 2101
-
2107
[3]
NEUROMEDIN-N - HIGH-AFFINITY INTERACTION WITH BRAIN NEUROTENSIN RECEPTORS AND RAPID INACTIVATION BY BRAIN SYNAPTIC PEPTIDASES
CHECLER, F
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
CHECLER, F
VINCENT, JP
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
VINCENT, JP
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
KITABGI, P
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1986,
126
(03)
: 239
-
244
[4]
POTENTIATION BY THIORPHAN AND BESTATIN OF THE NALOXONE-INSENSITIVE ANALGESIC EFFECTS OF NEUROTENSIN AND NEUROMEDIN-N
COQUEREL, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
COQUEREL, A
DUBUC, I
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
DUBUC, I
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
KITABGI, P
COSTENTIN, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
COSTENTIN, J
[J].
NEUROCHEMISTRY INTERNATIONAL,
1988,
12
(03)
: 361
-
366
[5]
CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR THE CANINE NEUROTENSIN NEUROMEDIN N-PRECURSOR
DOBNER, PR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
DOBNER, PR
BARBER, DL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
BARBER, DL
VILLAKOMAROFF, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
VILLAKOMAROFF, L
MCKIERNAN, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
MCKIERNAN, C
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1987,
84
(10)
: 3516
-
3520
[6]
HYPOTHERMIC EFFECT OF NEUROMEDIN-N IN MICE AND ITS POTENTIATION BY PEPTIDASE INHIBITORS
DUBUC, I
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
DUBUC, I
NOUEL, D
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
NOUEL, D
COQUEREL, A
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
COQUEREL, A
MENARD, JF
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
MENARD, JF
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
KITABGI, P
COSTENTIN, J
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
COSTENTIN, J
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1988,
151
(01)
: 117
-
121
[7]
ELEVATION OF PLASMA NEUROTENSIN DURING LIPID PERFUSION OF RAT SMALL-INTESTINE
FERRIS, CF
论文数:
0
引用数:
0
h-index:
0
FERRIS, CF
HAMMER, RA
论文数:
0
引用数:
0
h-index:
0
HAMMER, RA
LEEMAN, SE
论文数:
0
引用数:
0
h-index:
0
LEEMAN, SE
[J].
PEPTIDES,
1981,
2
: 263
-
266
[8]
KALIVAS PW, 1986, J PHARMACOL EXP THER, V238, P1126
[9]
KISLAUSKIS E, 1988, J BIOL CHEM, V263, P4963
[10]
NEW PROCEDURES FOR PREPARATION AND ISOLATION OF CONJUGATES OF PROTEINS AND A SYNTHETIC COPOLYMER OF D-AMINO ACIDS AND IMMUNOCHEMICAL CHARACTERIZATION OF SUCH CONJUGATES
LIU, FT
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
LIU, FT
ZINNECKER, M
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
ZINNECKER, M
HAMAOKA, T
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
HAMAOKA, T
KATZ, DH
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
KATZ, DH
[J].
BIOCHEMISTRY,
1979,
18
(04)
: 690
-
697
←
1
2
3
→
共 21 条
[1]
CARRAWAY R, 1973, J BIOL CHEM, V248, P6854
[2]
POTENTIAL PRECURSORS TO NEUROMEDIN-N IN THE CAT AND THEIR PROCESSING BY PEPSIN
CARRAWAY, RE
论文数:
0
引用数:
0
h-index:
0
CARRAWAY, RE
MITRA, SP
论文数:
0
引用数:
0
h-index:
0
MITRA, SP
[J].
ENDOCRINOLOGY,
1987,
120
(05)
: 2101
-
2107
[3]
NEUROMEDIN-N - HIGH-AFFINITY INTERACTION WITH BRAIN NEUROTENSIN RECEPTORS AND RAPID INACTIVATION BY BRAIN SYNAPTIC PEPTIDASES
CHECLER, F
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
CHECLER, F
VINCENT, JP
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
VINCENT, JP
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
FAC SCI NICE,CTR BIOCHIM,CNRS,F-06034 NICE,FRANCE
KITABGI, P
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1986,
126
(03)
: 239
-
244
[4]
POTENTIATION BY THIORPHAN AND BESTATIN OF THE NALOXONE-INSENSITIVE ANALGESIC EFFECTS OF NEUROTENSIN AND NEUROMEDIN-N
COQUEREL, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
COQUEREL, A
DUBUC, I
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
DUBUC, I
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
KITABGI, P
COSTENTIN, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
UNIV NICE, FAC SCI, CTR BIOCHIM, CNRS, F-06034 NICE, FRANCE
COSTENTIN, J
[J].
NEUROCHEMISTRY INTERNATIONAL,
1988,
12
(03)
: 361
-
366
[5]
CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR THE CANINE NEUROTENSIN NEUROMEDIN N-PRECURSOR
DOBNER, PR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
DOBNER, PR
BARBER, DL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
BARBER, DL
VILLAKOMAROFF, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
VILLAKOMAROFF, L
MCKIERNAN, C
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MASSACHUSETTS,MED CTR,DEPT PHYSIOL,WORCESTER,MA 01605
MCKIERNAN, C
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1987,
84
(10)
: 3516
-
3520
[6]
HYPOTHERMIC EFFECT OF NEUROMEDIN-N IN MICE AND ITS POTENTIATION BY PEPTIDASE INHIBITORS
DUBUC, I
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
DUBUC, I
NOUEL, D
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
NOUEL, D
COQUEREL, A
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
COQUEREL, A
MENARD, JF
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
MENARD, JF
KITABGI, P
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
KITABGI, P
COSTENTIN, J
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS, UNITE NEUROPSYCHOCHARMACOL EXPTL 1170, F-76800 ST ETIENNE DU ROUVRAY, FRANCE
COSTENTIN, J
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1988,
151
(01)
: 117
-
121
[7]
ELEVATION OF PLASMA NEUROTENSIN DURING LIPID PERFUSION OF RAT SMALL-INTESTINE
FERRIS, CF
论文数:
0
引用数:
0
h-index:
0
FERRIS, CF
HAMMER, RA
论文数:
0
引用数:
0
h-index:
0
HAMMER, RA
LEEMAN, SE
论文数:
0
引用数:
0
h-index:
0
LEEMAN, SE
[J].
PEPTIDES,
1981,
2
: 263
-
266
[8]
KALIVAS PW, 1986, J PHARMACOL EXP THER, V238, P1126
[9]
KISLAUSKIS E, 1988, J BIOL CHEM, V263, P4963
[10]
NEW PROCEDURES FOR PREPARATION AND ISOLATION OF CONJUGATES OF PROTEINS AND A SYNTHETIC COPOLYMER OF D-AMINO ACIDS AND IMMUNOCHEMICAL CHARACTERIZATION OF SUCH CONJUGATES
LIU, FT
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
LIU, FT
ZINNECKER, M
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
ZINNECKER, M
HAMAOKA, T
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
HAMAOKA, T
KATZ, DH
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
SCRIPPS CLIN & RES FDN,DEPT CELLULAR & DEV IMMUNOL,LA JOLLA,CA 92037
KATZ, DH
[J].
BIOCHEMISTRY,
1979,
18
(04)
: 690
-
697
←
1
2
3
→