USE OF CYCLODEXTRINS IN CAPILLARY ZONE ELECTROPHORESIS FOR THE SEPARATION OF OPTICAL ISOMERS - RESOLUTION OF RACEMIC TRYPTOPHAN DERIVATIVES

被引：36

作者：

NARDI, A ^{[1
]}

OSSICINI, L ^{[1
]}

FANALI, S ^{[1
]}

机构：

[1] CNR,IST CROMATOG,AREA RIC ROMA,CP 10,I-00016 MONTEROTONDO,ITALY

来源：

CHIRALITY | 1992年 / 4卷 / 01期

关键词：

CAPILLARY ZONE ELECTROPHORESIS; ENANTIOMERS; CYCLODEXTRINS; TRYPTOPHAN DERIVATIVES;

D O I：

10.1002/chir.530040112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study capillary zone electrophoresis has been used for the separation of racemic tryptophan derivatives in their enantiomers. The effect of cyclodextrins with different shape, added to the background electrolyte, on the migration time of 10 compounds, including methyl tryptophan, hydroxy tryptophan, and tryptophan ester derivatives, has been studied. Furthermore, the effect of cyclodextrins with different shape and that of the composition of the background electrolyte on the enantiomer resolution are discussed. Among different cyclodextrins used alpha-cyclodextrin and heptakis(2,6-di-O-methyl)-beta-cyclodextrin were found to possess the best complexing capacity and thus the resolution power toward analysed compounds.

引用

页码：56 / 61

页数：6

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