MOLECULAR CHARACTERIZATION OF HUMAN CD94 - A TYPE-II MEMBRANE GLYCOPROTEIN RELATED TO THE C-TYPE LECTIN SUPERFAMILY

被引:200
作者
CHANG, CW
RODRIGUEZ, A
CARRETERO, M
LOPEZBOTET, M
PHILLIPS, JH
LANIER, LL
机构
[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT HUMAN IMMUNOL, PALO ALTO, CA 94304 USA
[2] UNIV AUTONOMA MADRID, HOSP PRINCESA, SECC INMUNOL, MADRID, SPAIN
关键词
CD94; C-TYPE LECTIN; NATURAL KILLER CELL;
D O I
10.1002/eji.1830250904
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) cells preferentially express several genes of the C-type lectin superfamily which have been implicated in the regulation of NK cell function. We demonstrate that CD94 is a type II membrane protein encoded by a unique gene of the C-type lectin superfamily. While homology of CD94 with the NK cell-associated NKR-P1 and NKG2 C-type lectin genes is limited to the structural motifs conserved in the carbohydrate recognition domain, all of these genes are on human chromosome 12, the syntenic of mouse chromosome 6, where genes of the NK complex (NKR-P1 and Ly-49) are located. An unexpected feature of CD94 is the essential absence of a cytoplasmic domain, implying that association with other receptors may be necessary for the function of this molecule.
引用
收藏
页码:2433 / 2437
页数:5
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