The effects of anti-inflammatory drugs, that is, aspirin, cinchophen, cortisone, indo-methacin and phenylbutazone, on the output of plasma from the gastric mucosa and the volume of gastric juice were studied in the rat. Intravenously administered Pontamine Sky Blue dye was used as an indicator of the amount of plasma. When the drugs were allowed to remain in contact with the gastric mucosa for 2 hours, only aspirin increased the output of plasma. In the normal stomach filled with physiological saline, aspirin and cinchophen administered intraduodenally reduced both the output of plasma and the volume of gastric juice. In the irritated stomach filled with 0.7% acetic acid all the drugs administered intraduodenally markedly or slightly reduced the output of plasma and the volume of gastric juice, when administered intraperitoneally cinchophen markedly reduced them. Three plant extracts, that is, crude Saikosides, FM 100, and Paeoniflorin were also tested. There was a considerable correlation between the reduction in the output of plasma and in the volume of gastric juicc. Some possible relationships between drug-induced gastric disorders and the output of plasma and the volume of gastric juice were discussed. © 1969, The Japanese Pharmacological Society. All rights reserved.
