REINVESTIGATION OF THE PREPARATION OF IODOANTIPYRINE-I-131-4 FROM I-131-IODIDE

被引：18

作者：

ROBINSON, GD ^{[1
]}

LEE, AW ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,DIV NUCL MED,LOS ANGELES,CA 90024

来源：

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1979年 / 30卷 / 06期

关键词：

D O I：

10.1016/0020-708X(79)90021-8

中图分类号：

TL [原子能技术]; O571 [原子核物理学];

学科分类号：

0827 ; 082701 ;

摘要：

Radioiodine labeled 4-iodoantipyrine (4-IAP) is rapidly formed from radioiodide and nonradioactive 4-IAP or 4-bromoantipyrine (4-BrAP) at 100°C in acidic aqueous solution. Quantitative conversion to labeled 4-IAP is observed between pH 2 and 6 when 4-IAP is the nonradioactive starting material. This is in contrast to previous reports which found rapid incorporation only under limited conditions. When 4-BrAP is used, maximum yields of 80% are found between pH 1.5 and 2.5. Mechanistic implications of these differences are not clear. Labeled 4-IAP(≥98% radiochemically pure) is separated from radioiodide by TLC or anion-exchange chromatography. © 1979.

引用

页码：365 / 367

页数：3